5CZY


Conserved Protein Domain Family
SET_LegAS4-like
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cd10522: SET_LegAS4-like 
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins
LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.
Links
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Statistics
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PSSM-Id: 380920
Aligned: 16 rows
Threshold Bit Score: 122.45
Created: 26-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative activeSAM bindingcatalytic
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens SETD2 (5V21) binds H3K36M peptide and SAM.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                            ##                #                         #######       
5CZY_A      51 RTDLVMVQSVhllr-----ktgGRGLFAREdIPKGTCIGIYTGEVYSe-----qEFEQYLKEHvgsDKSYAMYVGg---- 116  Legionella pneum...
OUU72038    22 EIRTSTIKGA------------GLGLFTKAtIQTEDTIGYYTGRVIDe------IQFNDPKRP---FSAYPLWITrn--- 77   Coraliomargarita...
OLQ01568  1113 RVEASGLGPGa-----------GLGLFAAEaLEAGAVVAQYSGDLHDlrt-sraLEDQAYVMRl--GPTGPSKDEias-- 1176 Symbiodinium mic...
ADK79669    69 SFGIASVDKDi-----------GLGLFAAEpLKREDFVGEYTGIVREareidadEIDAAGHYPddwAWDYPVDIPgl--- 134  Sediminispirocha...
KKP35323    97 KCYIKKISDQv-----------GYGCFAAEtIKAYELVSEYTGLIKTs------VTDTQYNWE---IPLMFFYNNmp--- 153  candidate divisi...
Q9JS29      89 PVSVCWINAHv-----------GYGVFARDeIAPWTYIGEYTGILRHrqa--iwMDENDYCFR---YPMPLFTLRy---- 148  Chlamydophila pn...
EEY61811   116 KVAIGHVSLLshv------eekPLGLFAAEdLACYEFLGEYTGVIKVg------MSEMNEFDPy--GISYPSVYEgg--- 178  Phytophthora inf...
OLQ07489    55 SVFVRRIGVVdgv-------diGLGLFTRRaVAKGTFLGEYVGVMTRr------TCEEDGVYG---FSLPVVDPD----- 113  Symbiodinium mic...
AHE67785    46 PIFIALVPRLshi-------pnAFGAFASR-RIAKGEEFVYAGKRLT-------SKEASSART---EYLYELSRD----- 102  Legionella oakri...
OBT60725   270 RVDYPCLQVHqyppypsapnmiNKGVMAMQtFESDEFIGEYVGILLPpgr--adPSIRRNVFA---DDVYTIDLNaaviv 344  Pseudogymnoascus...

Feature 1                                 #####          #                #          ######## 
5CZY_A     117 --------------RVIDAARK-GNLTRYINFSDs--qDNAEFVETTln-rKKVAKVITTKNIKaGQQLLINYNTYEEQ 177  Legionella pneumo...
OUU72038    78 -------------hIIVGEGPK-ANYTRYINHSLr---PNAFLIVSTr---WKTARFEAIQTIHpGEEIFFNYGDDYWD 136  Coraliomargarita ...
OLQ01568  1177 ------------gcIYVDAGPHkELWARYINDCRnpqrYNLELVCRPq---RHFAELYASRPIAqGEELFFDYGEKYWD 1240 Symbiodinium micr...
ADK79669   135 ------------ppLEIDAATE-GNPLRYVNHSLf---PNLRPDHFLld-gVWVIIFVADRDIErGEELTIDYGDAYWS 196  Sediminispirochae...
KKP35323   154 ------------ysLYMDGKNY-GNFMRFVNASKn---PNIDVRYIFdksgYPHVLYIANKNIIkGEQLLVSYGKKYWE 216  candidate divisio...
Q9JS29     149 --------------FTIDSGKQ-GNVTRFINHSEq---PNAEAIGVFse-gLFHVIIRTIAPIYaGQEICYHYGPLYWK 208  Chlamydophila pne...
EEY61811   179 -------------nLYVSASEY-GNSIRCINHSAt---PNARFVPMVhn-gILRIFCFVIHEIEeGDQIFVNYGPSYWK 239  Phytophthora infe...
OLQ07489   114 --------------LVVDAKKF-GNLCRLINHSDd--dWNAELMSVHhe-gLLHVMCRATRDLMpEEQVFIHYGKRYWM 174  Symbiodinium micr...
AHE67785   103 --------------VVEDCEEV-GNATRFVNHSAq--yFNLYPEIREtpegKEYIAYVALRDIEpGEQLLIHYGPNYNY 164  Legionella oakrid...
OBT60725   345 ringetttmpgvkiADVSAGWK-GNWTRFINTSPrkadWNIELVQWMia-dRIRIMVRTIRPILfGEELIGSYGTDYMK 421  Pseudogymnoascus ...

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