6BX3


Conserved Protein Domain Family
SET_SET1
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cd20072: SET_SET1 
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins
The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).
Links
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Statistics
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PSSM-Id: 380998
Aligned: 8 rows
Threshold Bit Score: 279.694
Created: 2-Nov-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens mixed-lineage leukemia protein MLL1 binds cofactor product S-adenosylhomocysteine and histone peptide through its SET domain.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           ####                #                         ######       
6BX3_E     128 ELLSLNQLNKRKKPVMFARSaIHNWGLYALDSIAAKEMIIEYVGERIRQpVAEMREKRYLKngiGSSYLFRVDeNTVIDA 207  Saccharomyces ce...
Q9Y7R4     769 DLLRFNALKARKKQLHFGPSrIHTLGLFAMENIDKNDMVIEYIGEIIRQrVADNREKNYVRegiGDSYLFRIDeDVIVDA 848  Schizosaccharomy...
Q8X0S9    1159 DVLRFNQLKKRKKPVKFARSaIHNWGLYAMENINKDDMIIEYVGEEVRQqIAELREARYLKsgiGSSYLFRIDdNTVIDA 1238 Neurospora crass...
P38827     926 ELLSLNQLNKRKKPVMFARSaIHNWGLYALDSIAAKEMIIEYVGERIRQpVAEMREKRYLKngiGSSYLFRVDeNTVIDA 1005 Saccharomyces ce...
Q54HS3    1335 DPITLASLKSRRKRIKFERSdIHDWGLFAMETISAKDMVIEYIGEVIRQkVADEREKRYVKkgiGSSYLFRVDdDTIIDA 1414 Dictyostelium di...
KTW31398   888 DILRFNALKVRKKQLKFSKSpIHNWGLYAMEHIDMGDMVIEYVGEIVRQtVADIRERQYQRqgiGSSYLFRIDdDTVVDA 967  Pneumocystis car...
KJE92663  1161 DTFSLDMLKSRKKLLKFQRSgIHAFGLFSQENISANDLVIEYVGEVIRQsISDIREHHYERrgiGSSYFFRIDeDHVVDA 1240 Capsaspora owcza...
Q4PB36    1315 DIFKFNQLRTRKKQLKFAKSpIHDWGLYAMELIPAGDMVIEYVGEVVRQqVADEREKQYERqgnFSTYLFRVDdDLVVDA 1394 Ustilago maydis 521

Feature 1            ######       ###        #               ######         ####      
6BX3_E     208 TKKGGIARFINHCCdPNCTAKIIKVggRRRIVIYALRDIAaSEELTYDYKFErekdDEERLPCLCGAPNCK 278  Saccharomyces cerevisiae ...
Q9Y7R4     849 TKKGNIARFINHSCaPNCIARIIRVegKRKIVIYADRDIMhGEELTYDYKFPe---EADKIPCLCGAPTCR 916  Schizosaccharomyces pombe...
Q8X0S9    1239 TKKGGIARFINHSCmPNCTAKIIKVegSKRIVIYALRDIAqNEELTYDYKFEreigSTDRIPCLCGTAACK 1309 Neurospora crassa OR74A
P38827    1006 TKKGGIARFINHCCdPNCTAKIIKVggRRRIVIYALRDIAaSEELTYDYKFErekdDEERLPCLCGAPNCK 1076 Saccharomyces cerevisiae ...
Q54HS3    1415 TFKGNLARFINHCCdPNCIAKVLTIgnQKKIIIYAKRDINiGEEITYDYKFPi---EDVKIPCLCKSPKCR 1482 Dictyostelium discoideum
KTW31398   968 TKKGNIARFINHSCdPSCTAKIIRVegEKKIVIYAHRDIEkGEEITYDYKFPi---EDVKIPCLCGAKVCR 1035 Pneumocystis carinii B80
KJE92663  1241 TYKGNLARFMNHCCePNCYAKIIMVdgHQRIVIYSKRDIKkGEEITYDYKFPy---EENKIPCLCGAVNCK 1308 Capsaspora owczarzaki ATC...
Q4PB36    1395 THKGNIARLMNHCCtPNCNAKILTLngEKRIVLFAKTAIRaGEELTYDYKFQssadDEDAIPCLCGSPGCR 1465 Ustilago maydis 521

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