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BRCA1 BRCA1 DNA repair associated [ Macaca fascicularis (crab-eating macaque) ]

Gene ID: 102121313, updated on 7-Jun-2024

Summary

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Gene symbol
BRCA1
Gene description
BRCA1 DNA repair associated
See related
Ensembl:ENSMFAG00000043956
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca fascicularis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_05 current T2T-MFA8v1.0 (GCF_037993035.1) 16 NC_088390.1 (64115383..64201440, complement)
102 previous assembly MFA1912RKSv2 (GCF_012559485.2) 16 NC_052270.1 (25193845..25280198)

Chromosome 16 - NC_088390.1Genomic Context describing neighboring genes Neighboring gene vesicle amine transport 1 Neighboring gene Rho family GTPase 2 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene NBR1 autophagy cargo receptor Neighboring gene transmembrane protein 106A Neighboring gene coiled-coil domain containing 200

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma. Roncaglioni MC, et al. Haematologica, 1989 Mar-Apr. PMID 2501168
  2. Rapid evolution of BRCA1 and BRCA2 in humans and other primates. Lou DI, et al. BMC Evol Biol, 2014 Jul 11. PMID 25011685, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein
Names
BRCA1 homologue
breast cancer 1, early onset
breast cancer type 1 susceptibility protein homolog
XP_015293339.3
XP_045231864.1
XP_065388481.1
XP_065388482.1
XP_065388483.1
XP_065388484.1
XP_065388485.1
XP_065388486.1
XP_065388487.1
XP_065388488.1
XP_065388489.1
XP_065388490.1
XP_065388491.1
XP_065388492.1
XP_065388493.1
XP_065388494.1
XP_065388495.1
XP_065388496.1
XP_065388497.1
XP_065388498.1
XP_065388499.1
XP_065388501.1
XP_065388502.1
XP_065388503.1
XP_065388504.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_037993035.1-RS_2024_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference T2T-MFA8v1.0

Genomic

  1. NC_088390.1 Reference T2T-MFA8v1.0

    Range
    64115383..64201440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_065532416.1 → XP_065388488.1  breast cancer type 1 susceptibility protein isoform X1

  2. XM_065532409.1 → XP_065388481.1  breast cancer type 1 susceptibility protein isoform X1

  3. XM_065532412.1 → XP_065388484.1  breast cancer type 1 susceptibility protein isoform X1

  4. XM_065532415.1 → XP_065388487.1  breast cancer type 1 susceptibility protein isoform X1

  5. XM_065532410.1 → XP_065388482.1  breast cancer type 1 susceptibility protein isoform X1

  6. XM_065532411.1 → XP_065388483.1  breast cancer type 1 susceptibility protein isoform X1

  7. XM_065532419.1 → XP_065388491.1  breast cancer type 1 susceptibility protein isoform X3

  8. XM_065532417.1 → XP_065388489.1  breast cancer type 1 susceptibility protein isoform X2

  9. XM_065532422.1 → XP_065388494.1  breast cancer type 1 susceptibility protein isoform X6

  10. XM_065532421.1 → XP_065388493.1  breast cancer type 1 susceptibility protein isoform X5

  11. XM_065532420.1 → XP_065388492.1  breast cancer type 1 susceptibility protein isoform X4

  12. XM_065532418.1 → XP_065388490.1  breast cancer type 1 susceptibility protein isoform X3

  13. XM_015437853.3 → XP_015293339.3  breast cancer type 1 susceptibility protein isoform X2

  14. XM_065532414.1 → XP_065388486.1  breast cancer type 1 susceptibility protein isoform X1

  15. XM_065532413.1 → XP_065388485.1  breast cancer type 1 susceptibility protein isoform X1

  16. XM_065532427.1 → XP_065388499.1  breast cancer type 1 susceptibility protein isoform X9

  17. XM_065532432.1 → XP_065388504.1  breast cancer type 1 susceptibility protein isoform X14

  18. XM_065532431.1 → XP_065388503.1  breast cancer type 1 susceptibility protein isoform X13

  19. XM_065532430.1 → XP_065388502.1  breast cancer type 1 susceptibility protein isoform X12

  20. XM_065532429.1 → XP_065388501.1  breast cancer type 1 susceptibility protein isoform X11

  21. XM_065532423.1 → XP_065388495.1  breast cancer type 1 susceptibility protein isoform X7

  22. XM_065532424.1 → XP_065388496.1  breast cancer type 1 susceptibility protein isoform X7

  23. XM_065532426.1 → XP_065388498.1  breast cancer type 1 susceptibility protein isoform X8

  24. XM_065532425.1 → XP_065388497.1  breast cancer type 1 susceptibility protein isoform X8

  25. XM_045375929.2 → XP_045231864.1  breast cancer type 1 susceptibility protein isoform X10

    Conserved Domains (2) summary
    cd17721
    Location:469 → 566
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:361 → 457
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001301366.1: Suppressed sequence

    Description
    NM_001301366.1: This RefSeq record was removed as a result of standard genome annotation processing. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
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