aplnrb apelin receptor b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aplnrbprovided by ZNC
Official Full Name: apelin receptor bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050913-90
See related: Ensembl:ENSDARG00000036670 AllianceGenome:ZFIN:ZDB-GENE-050913-90
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: grn; APLNR2b; Agtrl1a; agtrl1b; zgc:114063
Summary: Enables apelin receptor activity. Involved in cardiac muscle tissue development; cell migration; and gastrulation with mouth forming second. Acts upstream of or within with a positive effect on determination of heart left/right asymmetry and determination of liver left/right asymmetry. Acts upstream of or within several processes, including angioblast cell migration from lateral mesoderm to midline; endodermal cell differentiation; and mesodermal cell migration. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including angioblastic mesenchymal cell; blastodisc; cardiovascular system; mesoderm; and pleuroperitoneal region. Orthologous to human APLNR (apelin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (8629275..8631358)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (8670575..8672658)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aplnra/b coordinates organ LR patterning in an apela/apln ligand-dependent manner using distinct mechanisms at different stages.
Title: Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms.
These results favour a model in which Apelin receptor is required to fine-tune Nodal output, acting as a specific rheostat for the Nodal/TGFbeta pathway during the earliest stages of cardiogenesis.
Title: The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables apelin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables apelin receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angioblast cell migration from lateral mesoderm to midline	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within angioblast cell migration from lateral mesoderm to midline	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apelin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in blood vessel development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coronary vasculature development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_positive_effect determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect determination of liver left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endodermal cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cAMP-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inhibitory G protein-coupled receptor phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of nodal signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: apelin receptor B

Names: G-protein coupled receptor APJ B; angiotensin II receptor-like 1b; angiotensin receptor-like 1b; grinch; protein grinch

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.