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    Mlp84B Muscle LIM protein at 84B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40849, updated on 10-May-2024

    Summary

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    Official Symbol
    Mlp84Bprovided by FlyBase
    Official Full Name
    Muscle LIM protein at 84Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014863
    Locus tag
    Dmel_CG1019
    See related
    AllianceGenome:FB:FBgn0014863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1019; DLim-3; Dmel\CG1019; DmLIM-3; dMlp84B; Mlmu84B; mlp; Mlp; MLP; mlp84B; Mlp84b; MLP84B
    Summary
    A structural constituent of muscle. Involved in muscle tissue development and sarcomere organization. Located in Z disc and nucleus. Colocalizes with actin cytoskeleton. Is expressed in adult head; adult heart; muscle system; and trunk mesoderm. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to several human genes including CSRP1 (cysteine and glycine rich protein 1) and CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Mlp84B in Genome Data Viewer
    Location:
    84C1-84C1; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7112850..7117732, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2939244..2943454, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene enhancer of yellow 2b Neighboring gene Alhambra Neighboring gene long non-coding RNA:CR45906 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation. Clark KA, et al. Am J Physiol Cell Physiol, 2011 Aug. PMID 21562304, Free PMC Article
    2. The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function. Mery A, et al. J Exp Biol, 2008 Jan. PMID 18083727
    3. Two muscle-specific LIM proteins in Drosophila. Stronach BE, et al. J Cell Biol, 1996 Sep. PMID 8794860, Free PMC Article
    4. The function of Lmpt in Drosophila heart tissue. She M, et al. Biochem Biophys Res Commun, 2022 Jul 5. PMID 35500437
    5. Drosophila melanogaster muscle LIM protein and alpha-actinin function together to stabilize muscle cytoarchitecture: a potential role for Mlp84B in actin-crosslinking. Clark KA, et al. Cytoskeleton (Hoboken), 2013 Jun. PMID 23606669, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest mlp84B contributes to wing muscle stiffness and is necessary for maximum work and power generation.
      Title: Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation.
    2. These data demonstrate that Mlp84B is essential for normal cardiac function.
      Title: The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function.
    3. Results reveal a role for Mlp84B in maintaining muscle structural integrity, and suggest Mlp84B and D-titin cooperate to stabilize muscle sarcomeres.
      Title: The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of muscle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables structural constituent of muscle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle tissue development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sarcomere organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc HDA PubMed 
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    muscle LIM protein at 84B
    Names
    CG1019-PA
    CG1019-PB
    CG1019-PC
    LIM protein 84B
    Mlp84B-PA
    Mlp84B-PB
    Mlp84B-PC
    Muscle-specific LIM protein at 84B
    muscle LIM protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7112850..7117732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316489.1 → NP_001303418.1  muscle LIM protein at 84B, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2J1, Q24400, Q9VI62
      Conserved Domains (2) summary
      cd09326
      Location:120 → 173
      LIM_CRP_like; The LIM domains of Cysteine Rich Protein (CRP) family
      cd09404
      Location:11 → 64
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A

    2. NM_057774.5 → NP_477122.1  muscle LIM protein at 84B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477122.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2J1, Q24400, Q9VI62
      Related
      FBpp0081133
      Conserved Domains (2) summary
      cd09326
      Location:120 → 173
      LIM_CRP_like; The LIM domains of Cysteine Rich Protein (CRP) family
      cd09404
      Location:11 → 64
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A

    3. NM_169173.3 → NP_731134.1  muscle LIM protein at 84B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2J1, Q24400, Q9VI62
      Related
      FBpp0081134
      Conserved Domains (2) summary
      cd09326
      Location:120 → 173
      LIM_CRP_like; The LIM domains of Cysteine Rich Protein (CRP) family
      cd09404
      Location:11 → 64
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24400.1 Q24400

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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