U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    tlyA 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885396, updated on 6-Oct-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    tlyA
    Gene description
    16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA
    Locus tag
    Rv1694
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000962.3 (1917940..1918746)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene phosphatase Neighboring gene hypothetical protein Neighboring gene inorganic polyphosphate/ATP-NAD kinase Neighboring gene DNA repair protein RecN

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. 50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA. Laughlin ZT, et al. Proc Natl Acad Sci U S A, 2022 Apr 5. PMID 35357969, Free PMC Article
    2. Assessing capreomycin resistance on tlyA deficient and point mutation (G695A) Mycobacterium tuberculosis strains using multi-omics analysis. Zhao J, et al. Int J Med Microbiol, 2019 Nov. PMID 31279617
    3. Molecular analysis of streptomycin-resistance associating genes in Mycobacterium tuberculosis isolates from Nepal. Shrestha D, et al. Tuberculosis (Edinb), 2020 Dec. PMID 32829153
    4. A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis. Witek MA, et al. J Biol Chem, 2017 Feb 3. PMID 28031456, Free PMC Article
    5. Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis. Rahman MA, et al. J Biol Chem, 2015 Jun 5. PMID 25847237, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA.
      Title: 50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA.
    2. Molecular analysis of streptomycin-resistance associating genes in Mycobacterium tuberculosis isolates from Nepal.
      Title: Molecular analysis of streptomycin-resistance associating genes in Mycobacterium tuberculosis isolates from Nepal.
    3. Capreomycin (CAP)-resistant Mycobacterium tuberculosis strain with tlyA deficiency is more resistant to CAP than the strain with point mutation. The greater drug tolerance is associated with the weakening of S-adenosyl-L-methionine-dependent methyltransferase activity and abnormal membrane lipid metabolism by suppression of fatty acid metabolism, promotion of glycolipid phospholipid and glycerolipid metabolism.
      Title: Assessing capreomycin resistance on tlyA deficient and point mutation (G695A) Mycobacterium tuberculosis strains using multi-omics analysis.
    4. findings thus reveal a novel motif requirement for SAM binding by TlyA and set the stage for future mechanistic studies of TlyA substrate recognition and modification that underpin Mtb sensitivity to capreomycin
      Title: A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis.
    5. M. tuberculosis employs TlyA as a host evasion factor, thereby contributing to its virulence.
      Title: Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis.
    6. A novel missense mutation in the overlap of tlyA and ppnK is involved in capreomycin resistance in Mycobacterium.
      Title: Characterization of a novel mutation in the overlap of tlyA and ppnK involved in capreomycin resistance in Mycobacterium.
    7. Studies indicate that mutations in the rrs, tlyA, eis promoter and gidB genes were associated with amikacin, kanamycin and capreomycin resistance.
      Title: Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic review.
    8. Rv1694 of Mycobacterium tuberculosis appears to contain two diverse functions such as haemolytic activity and ribosomal RNA methylation activity.
      Title: Molecular characterization of tlyA gene product, Rv1694 of Mycobacterium tuberculosis: a non-conventional hemolysin and a ribosomal RNA methyl transferase.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      1917940..1918746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216210.1 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216210.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1S5VHV2, A0A5B8YY71
      Conserved Domains (1) summary
      COG1189
      Location:3 → 248
      YqxC; Predicted rRNA methylase YqxC, contains S4 and FtsJ domains [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WJ63.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    -