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Ankylosing spondylitis(AS)

MedGen UID:
11561
Concept ID:
C0038013
Disease or Syndrome
Synonyms: AS; Disorder of joint of spine; Spondylarthropathies; spondylitis ankylosans
SNOMED CT: Marie-Strumpell spondylitis (9631008); Idiopathic ankylosing spondylitis (9631008); AS - Ankylosing spondylitis (9631008); Ankylosing spondylitis (9631008); Marie Strümpell spondylitis (9631008); Bekhterev's disease (9631008)
 
Monarch Initiative: MONDO:0005306
Orphanet: ORPHA825

Definition

An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnkylosing spondylitis

Professional guidelines

PubMed

Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X, Landewé RBM, Van den Bosch FE, Boteva B, Bremander A, Carron P, Ciurea A, van Gaalen FA, Géher P, Gensler L, Hermann J, de Hooge M, Husakova M, Kiltz U, López-Medina C, Machado PM, Marzo-Ortega H, Molto A, Navarro-Compán V, Nissen MJ, Pimentel-Santos FM, Poddubnyy D, Proft F, Rudwaleit M, Telkman M, Zhao SS, Ziade N, van der Heijde D
Ann Rheum Dis 2023 Jan;82(1):19-34. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223296. PMID: 36270658
Danve A, Deodhar A
Nat Rev Rheumatol 2022 Apr;18(4):205-216. Epub 2022 Mar 10 doi: 10.1038/s41584-022-00761-z. PMID: 35273385
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article

Recent clinical studies

Etiology

Li S, Chen M, Zhang Q, Fang M, Xiong W, Bai L
Front Immunol 2023;14:1120742. Epub 2023 Mar 20 doi: 10.3389/fimmu.2023.1120742. PMID: 37020551Free PMC Article
Garcia-Montoya L, Gul H, Emery P
F1000Res 2018;7 Epub 2018 Sep 21 doi: 10.12688/f1000research.14956.1. PMID: 30345001Free PMC Article
Wang R, Ward MM
Curr Opin Rheumatol 2018 Mar;30(2):137-143. doi: 10.1097/BOR.0000000000000475. PMID: 29227352Free PMC Article
Hanson A, Brown MA
Rheum Dis Clin North Am 2017 Aug;43(3):401-414. doi: 10.1016/j.rdc.2017.04.006. PMID: 28711142Free PMC Article
Sharan D, Rajkumar JS
Curr Rheumatol Rev 2017;13(2):121-125. doi: 10.2174/1573397112666161025112750. PMID: 27784233

Diagnosis

Taitt HA, Balakrishnan R
Emerg Med Clin North Am 2022 Feb;40(1):159-178. Epub 2021 Oct 29 doi: 10.1016/j.emc.2021.08.005. PMID: 34782086
Chen CW, Wei JC, Gu J, Yu D
Front Immunol 2021;12:822582. Epub 2021 Dec 23 doi: 10.3389/fimmu.2021.822582. PMID: 35003143Free PMC Article
Fiorillo MT, Haroon N, Ciccia F, Breban M
Front Immunol 2019;10:1232. Epub 2019 Jun 4 doi: 10.3389/fimmu.2019.01232. PMID: 31214188Free PMC Article
Wang R, Ward MM
Curr Opin Rheumatol 2018 Mar;30(2):137-143. doi: 10.1097/BOR.0000000000000475. PMID: 29227352Free PMC Article
Smith JA
Curr Allergy Asthma Rep 2015 Jan;15(1):489. doi: 10.1007/s11882-014-0489-6. PMID: 25447326

Therapy

Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H
Front Immunol 2022;13:891822. Epub 2022 Jul 22 doi: 10.3389/fimmu.2022.891822. PMID: 35935936Free PMC Article
Gottlieb AB, Deodhar A, Mcinnes IB, Baraliakos X, Reich K, Schreiber S, Bao W, Marfo K, Richards HB, Pricop L, Shete A, Trivedi V, Keefe D, Papavassilis CC, Jagiello P, Papanastasiou P, Mease PJ, Lebwohl M
Acta Derm Venereol 2022 Apr 27;102:adv00698. doi: 10.2340/actadv.v102.563. PMID: 35146532Free PMC Article
Fauny M, Moulin D, D'Amico F, Netter P, Petitpain N, Arnone D, Jouzeau JY, Loeuille D, Peyrin-Biroulet L
Ann Rheum Dis 2020 Sep;79(9):1132-1138. Epub 2020 Jul 21 doi: 10.1136/annrheumdis-2020-217927. PMID: 32719044
Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L
Arthritis Care Res (Hoboken) 2019 Oct;71(10):1285-1299. Epub 2019 Aug 21 doi: 10.1002/acr.24025. PMID: 31436026Free PMC Article
Dagfinrud H, Kvien TK, Hagen KB
Cochrane Database Syst Rev 2008 Jan 23;2008(1):CD002822. doi: 10.1002/14651858.CD002822.pub3. PMID: 18254008Free PMC Article

Prognosis

Li Z, Khan MK, van der Linden SM, Winkens B, Villiger PM, Baumberger H, van Zandwijk H, Khan MA, Brown MA
Ann Rheum Dis 2023 Dec;82(12):1558-1567. Epub 2023 Sep 7 doi: 10.1136/ard-2023-224434. PMID: 37679034
Watts RA, Scott DG
Best Pract Res Clin Rheumatol 2016 Oct;30(5):916-931. Epub 2016 Nov 9 doi: 10.1016/j.berh.2016.10.008. PMID: 27964796
Raychaudhuri SP, Deodhar A
J Autoimmun 2014 Feb-Mar;48-49:128-33. Epub 2014 Feb 16 doi: 10.1016/j.jaut.2014.01.015. PMID: 24534717
Bakland G, Nossent HC
Curr Rheumatol Rep 2013 Sep;15(9):351. doi: 10.1007/s11926-013-0351-1. PMID: 23888360
Zochling J, Smith EU
Best Pract Res Clin Rheumatol 2010 Dec;24(6):747-56. doi: 10.1016/j.berh.2011.02.002. PMID: 21665123

Clinical prediction guides

Park YG, Goh TS, Kim DS, Jung SJ, Lee JS
Clin Orthop Surg 2023 Apr;15(2):249-256. Epub 2023 Jan 30 doi: 10.4055/cios22112. PMID: 37008970Free PMC Article
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
van der Heijde D, Braun J, Deodhar A, Baraliakos X, Landewé R, Richards HB, Porter B, Readie A
Rheumatology (Oxford) 2019 Mar 1;58(3):388-400. doi: 10.1093/rheumatology/key128. PMID: 29860356Free PMC Article
Braun J, Baraliakos X, Buehring B, Kiltz U, Fruth M
Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):35-42. Epub 2018 Oct 1 PMID: 30296971
Maksymowych WP
Curr Opin Rheumatol 2009 Jul;21(4):313-7. doi: 10.1097/bor.0b013e32832af481. PMID: 19496307

Recent systematic reviews

Webers C, Ortolan A, Sepriano A, Falzon L, Baraliakos X, Landewé RBM, Ramiro S, van der Heijde D, Nikiphorou E
Ann Rheum Dis 2023 Jan;82(1):130-141. Epub 2022 Oct 21 doi: 10.1136/ard-2022-223298. PMID: 36270657
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H
Front Immunol 2022;13:891822. Epub 2022 Jul 22 doi: 10.3389/fimmu.2022.891822. PMID: 35935936Free PMC Article
Hwang MC, Ridley L, Reveille JD
Clin Rheumatol 2021 Aug;40(8):3079-3093. Epub 2021 Mar 22 doi: 10.1007/s10067-021-05679-7. PMID: 33754220Free PMC Article
Millner JR, Barron JS, Beinke KM, Butterworth RH, Chasle BE, Dutton LJ, Lewington MA, Lim EG, Morley TB, O'Reilly JE, Pickering KA, Winzenberg T, Zochling J
Semin Arthritis Rheum 2016 Feb;45(4):411-27. Epub 2015 Aug 18 doi: 10.1016/j.semarthrit.2015.08.003. PMID: 26493464
Dean LE, Jones GT, MacDonald AG, Downham C, Sturrock RD, Macfarlane GJ
Rheumatology (Oxford) 2014 Apr;53(4):650-7. Epub 2013 Dec 9 doi: 10.1093/rheumatology/ket387. PMID: 24324212

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