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Cardiomegaly due to hypertension

MedGen UID:
151958
•Concept ID:
C0694541
•
Disease or Syndrome
Synonyms: Hypertensive cardiomegaly; Hypertensive Cardiomegaly
SNOMED CT: Cardiomegaly due to hypertension (275516004); Hypertensive cardiomegaly (275516004)

Definition

Abnormal enlargement of the heart resulting from long-standing hypertension. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiomegaly due to hypertension

Professional guidelines

PubMed

Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy.
Escobar-Lopez L, Ochoa JP, Royuela A, Verdonschot JAJ, Dal Ferro M, Espinosa MA, Sabater-Molina M, Gallego-Delgado M, Larrañaga-Moreira JM, Garcia-Pinilla JM, Basurte-Elorz MT, Rodríguez-Palomares JF, Climent V, Bermudez-Jimenez FJ, Mogollón-Jiménez MV, Lopez J, Peña-Peña ML, Garcia-Alvarez A, López-Abel B, Ripoll-Vera T, Palomino-Doza J, Bayes-Genis A, Brugada R, Idiazabal U, Mirelis JG, Dominguez F, Henkens MTHM, Krapels IPC, Brunner HG, Paldino A, Zaffalon D, Mestroni L, Sinagra G, Heymans SRB, Merlo M, Garcia-Pavia P
J Am Coll Cardiol 2022 Sep 20;80(12):1115-1126. doi: 10.1016/j.jacc.2022.06.040. PMID: 36109106Free PMC Article
Efficacy of echocardiography for differential diagnosis of left ventricular hypertrophy: special focus on speckle-tracking longitudinal strain.
Tanaka H
J Echocardiogr 2021 Jun;19(2):71-79. Epub 2021 Jan 18 doi: 10.1007/s12574-020-00508-3. PMID: 33460030Free PMC Article
Hypertension Canada's 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children.
Rabi DM, McBrien KA, Sapir-Pichhadze R, Nakhla M, Ahmed SB, Dumanski SM, Butalia S, Leung AA, Harris KC, Cloutier L, Zarnke KB, Ruzicka M, Hiremath S, Feldman RD, Tobe SW, Campbell TS, Bacon SL, Nerenberg KA, Dresser GK, Fournier A, Burgess E, Lindsay P, Rabkin SW, Prebtani APH, Grover S, Honos G, Alfonsi JE, Arcand J, Audibert F, Benoit G, Bittman J, Bolli P, Côté AM, Dionne J, Don-Wauchope A, Edwards C, Firoz T, Gabor JY, Gilbert RE, Grégoire JC, Gryn SE, Gupta M, Hannah-Shmouni F, Hegele RA, Herman RJ, Hill MD, Howlett JG, Hundemer GL, Jones C, Kaczorowski J, Khan NA, Kuyper LM, Lamarre-Cliche M, Lavoie KL, Leiter LA, Lewanczuk R, Logan AG, Magee LA, Mangat BK, McFarlane PA, McLean D, Michaud A, Milot A, Moe GW, Penner SB, Pipe A, Poppe AY, Rey E, Roerecke M, Schiffrin EL, Selby P, Sharma M, Shoamanesh A, Sivapalan P, Townsend RR, Tran K, Trudeau L, Tsuyuki RT, Vallée M, Woo V, Bell AD, Daskalopoulou SS
Can J Cardiol 2020 May;36(5):596-624. doi: 10.1016/j.cjca.2020.02.086. PMID: 32389335

Recent clinical studies

Etiology

Capsaicin improves hypertension and cardiac hypertrophy via SIRT1/NF-κB/MAPKs pathway in the hypothalamic paraventricular nucleus.
Jia XY, Jiang DL, Jia XT, Fu LY, Tian H, Liu KL, Qi J, Kang YM, Yu XJ
Phytomedicine 2023 Sep;118:154951. Epub 2023 Jul 7 doi: 10.1016/j.phymed.2023.154951. PMID: 37453193
Characterizing the hypertensive cardiovascular phenotype in the UK Biobank.
Elghazaly H, McCracken C, Szabo L, Malcolmson J, Manisty CH, Davies AH, Piechnik SK, Harvey NC, Neubauer S, Mohiddin SA, Petersen SE, Raisi-Estabragh Z
Eur Heart J Cardiovasc Imaging 2023 Sep 26;24(10):1352-1360. doi: 10.1093/ehjci/jead123. PMID: 37309807Free PMC Article
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Hypertensive heart disease.
Diamond JA, Phillips RA
Hypertens Res 2005 Mar;28(3):191-202. doi: 10.1291/hypres.28.191. PMID: 16097361
Cardiac baroreflexes and hypertension.
Head GA
Clin Exp Pharmacol Physiol 1994 Oct;21(10):791-802. doi: 10.1111/j.1440-1681.1994.tb02448.x. PMID: 7867230

Diagnosis

Characterizing the hypertensive cardiovascular phenotype in the UK Biobank.
Elghazaly H, McCracken C, Szabo L, Malcolmson J, Manisty CH, Davies AH, Piechnik SK, Harvey NC, Neubauer S, Mohiddin SA, Petersen SE, Raisi-Estabragh Z
Eur Heart J Cardiovasc Imaging 2023 Sep 26;24(10):1352-1360. doi: 10.1093/ehjci/jead123. PMID: 37309807Free PMC Article
Phenotyping the hypertensive heart.
Tadic M, Cuspidi C, Marwick TH
Eur Heart J 2022 Oct 11;43(38):3794-3810. doi: 10.1093/eurheartj/ehac393. PMID: 35869979
Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Cardiac baroreflexes and hypertension.
Head GA
Clin Exp Pharmacol Physiol 1994 Oct;21(10):791-802. doi: 10.1111/j.1440-1681.1994.tb02448.x. PMID: 7867230

Therapy

Sex, gender, and subclinical hypertensiveorgan damage-heart.
Cuspidi C, Gherbesi E, Sala C, Tadic M
J Hum Hypertens 2023 Aug;37(8):626-633. Epub 2022 Aug 27 doi: 10.1038/s41371-022-00750-5. PMID: 36030347
Pharmacotherapy for hypertension-induced left ventricular hypertrophy.
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Beta-blockers and heart failure.
Cruickshank JM
Indian Heart J 2010 Mar-Apr;62(2):101-10. PMID: 21180298
Hypertensive heart disease.
Diamond JA, Phillips RA
Hypertens Res 2005 Mar;28(3):191-202. doi: 10.1291/hypres.28.191. PMID: 16097361
Obesity, hypertension, and the heart.
Thakur V, Richards R, Reisin E
Am J Med Sci 2001 Apr;321(4):242-8. doi: 10.1097/00000441-200104000-00005. PMID: 11307866

Prognosis

Personality traits and hypertension-mediated organ damage.
Popiołek L, Siga O, Dzieża-Grudnik A, Popiołek I, Moląg M, Królczyk J, Grodzicki T, Walczewska J, Rutkowski K
Psychiatr Pol 2019 Oct 30;53(5):1003-1020. doi: 10.12740/PP/108453. PMID: 31955182
Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Masked hypertension: a systematic review.
Bobrie G, Clerson P, Ménard J, Postel-Vinay N, Chatellier G, Plouin PF
J Hypertens 2008 Sep;26(9):1715-25. doi: 10.1097/HJH.0b013e3282fbcedf. PMID: 18698202
Dippers versus non-dippers.
Verdecchia P, Schillaci G, Porcellati C
J Hypertens Suppl 1991 Dec;9(8):S42-4. PMID: 1839037

Clinical prediction guides

Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Chronotherapy in Nigerian hypertensives.
Okeahialam B, Ohihoin E, Ajuluchukwu J
Ther Adv Cardiovasc Dis 2011 Apr;5(2):113-8. Epub 2011 Mar 7 doi: 10.1177/1753944711402119. PMID: 21383004
Cardiac baroreflexes and hypertension.
Head GA
Clin Exp Pharmacol Physiol 1994 Oct;21(10):791-802. doi: 10.1111/j.1440-1681.1994.tb02448.x. PMID: 7867230
Heart and hypertension.
Fogari R, Zoppi A
Am J Hypertens 1989 Feb;2(2 Pt 2):16S-23S. doi: 10.1093/ajh/2.2.16s. PMID: 2522004

Recent systematic reviews

Prevalence of Pediatric Masked Hypertension and Risk of Subclinical Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.
Chung J, Robinson C, Sheffield L, Paramanathan P, Yu A, Ewusie J, Sanger S, Mitsnefes M, Parekh RS, Sinha MD, Rodrigues M, Thabane L, Dionne J, Chanchlani R
Hypertension 2023 Nov;80(11):2280-2292. Epub 2023 Sep 22 doi: 10.1161/HYPERTENSIONAHA.123.20967. PMID: 37737026
Prevalence of masked hypertension and its association with left ventricular hypertrophy in children and young adults with chronic kidney disease: a systematic review and meta-analysis.
Goulas I, Evripidou K, Doundoulakis I, Kollios K, Nika T, Chainoglou A, Kotsis V, Stabouli S
J Hypertens 2023 May 1;41(5):699-707. Epub 2023 Mar 1 doi: 10.1097/HJH.0000000000003402. PMID: 36883474
Pharmacotherapy for hypertension-induced left ventricular hypertrophy.
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Blood pressure and hypertension in athletes: a systematic review.
Berge HM, Isern CB, Berge E
Br J Sports Med 2015 Jun;49(11):716-23. Epub 2015 Jan 28 doi: 10.1136/bjsports-2014-093976. PMID: 25631543
Masked hypertension: a systematic review.
Bobrie G, Clerson P, Ménard J, Postel-Vinay N, Chatellier G, Plouin PF
J Hypertens 2008 Sep;26(9):1715-25. doi: 10.1097/HJH.0b013e3282fbcedf. PMID: 18698202

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