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Coronary artery spasm

MedGen UID:
3626
•Concept ID:
C0010073
•
Disease or Syndrome
Synonym: Coronary vasospasm
SNOMED CT: Coronary artery spasm (23687008); Coronary spasm (23687008)
 
HPO: HP:0025497
Monarch Initiative: MONDO:0005356

Definition

A brief and sudden narrowing of a coronary artery. [from HPO]

Professional guidelines

PubMed

Treatment of Angina: Where Are We?
Balla C, Pavasini R, Ferrari R
Cardiology 2018;140(1):52-67. Epub 2018 Jun 6 doi: 10.1159/000487936. PMID: 29874661
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990
Epidemiology, pathogenesis, and management of takotsubo syndrome.
Y-Hassan S, Tornvall P
Clin Auton Res 2018 Feb;28(1):53-65. Epub 2017 Sep 15 doi: 10.1007/s10286-017-0465-z. PMID: 28917022Free PMC Article

Recent clinical studies

Etiology

Myocardial Infarction with Nonobstructive Coronary Arteries.
Reynolds HR, Smilowitz NR
Annu Rev Med 2023 Jan 27;74:171-188. Epub 2022 Sep 30 doi: 10.1146/annurev-med-042921-111727. PMID: 36179347
Vasospastic angina: A literature review of current evidence.
Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O
Arch Cardiovasc Dis 2019 Jan;112(1):44-55. Epub 2018 Sep 7 doi: 10.1016/j.acvd.2018.08.002. PMID: 30197243
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990
Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need.
Ford TJ, Corcoran D, Berry C
Heart 2018 Feb;104(4):284-292. Epub 2017 Oct 13 doi: 10.1136/heartjnl-2017-311446. PMID: 29030424Free PMC Article
Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries.
Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF
Circulation 2015 Mar 10;131(10):861-70. Epub 2015 Jan 13 doi: 10.1161/CIRCULATIONAHA.114.011201. PMID: 25587100

Diagnosis

Myocardial Infarction with Nonobstructive Coronary Arteries.
Reynolds HR, Smilowitz NR
Annu Rev Med 2023 Jan 27;74:171-188. Epub 2022 Sep 30 doi: 10.1146/annurev-med-042921-111727. PMID: 36179347
Vasospastic angina: A literature review of current evidence.
Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O
Arch Cardiovasc Dis 2019 Jan;112(1):44-55. Epub 2018 Sep 7 doi: 10.1016/j.acvd.2018.08.002. PMID: 30197243
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990
Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need.
Ford TJ, Corcoran D, Berry C
Heart 2018 Feb;104(4):284-292. Epub 2017 Oct 13 doi: 10.1136/heartjnl-2017-311446. PMID: 29030424Free PMC Article
Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management.
Kounis NG
Clin Chem Lab Med 2016 Oct 1;54(10):1545-59. doi: 10.1515/cclm-2016-0010. PMID: 26966931

Therapy

Update on coronary artery spasm 2022 - A narrative review.
Seitz A, Martínez Pereyra V, Sechtem U, Ong P
Int J Cardiol 2022 Jul 15;359:1-6. Epub 2022 Apr 14 doi: 10.1016/j.ijcard.2022.04.011. PMID: 35429510
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990
Coronary artery spasm: review and update.
Hung MJ, Hu P, Hung MY
Int J Med Sci 2014;11(11):1161-71. Epub 2014 Aug 28 doi: 10.7150/ijms.9623. PMID: 25249785Free PMC Article
Variant angina and coronary artery spasm: the clinical spectrum, pathophysiology, and management.
Kusama Y, Kodani E, Nakagomi A, Otsuka T, Atarashi H, Kishida H, Mizuno K
J Nippon Med Sch 2011;78(1):4-12. doi: 10.1272/jnms.78.4. PMID: 21389642
Coronary artery spasm--1984.
Cheng TO
Chest 1984 Dec;86(6):918-26. doi: 10.1378/chest.86.6.918. PMID: 6499557

Prognosis

Vasospastic angina: A literature review of current evidence.
Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O
Arch Cardiovasc Dis 2019 Jan;112(1):44-55. Epub 2018 Sep 7 doi: 10.1016/j.acvd.2018.08.002. PMID: 30197243
Treatment of Angina: Where Are We?
Balla C, Pavasini R, Ferrari R
Cardiology 2018;140(1):52-67. Epub 2018 Jun 6 doi: 10.1159/000487936. PMID: 29874661
International standardization of diagnostic criteria for microvascular angina.
Ong P, Camici PG, Beltrame JF, Crea F, Shimokawa H, Sechtem U, Kaski JC, Bairey Merz CN; Coronary Vasomotion Disorders International Study Group (COVADIS)
Int J Cardiol 2018 Jan 1;250:16-20. Epub 2017 Sep 8 doi: 10.1016/j.ijcard.2017.08.068. PMID: 29031990
Kounis syndrome: an update on epidemiology, pathogenesis, diagnosis and therapeutic management.
Kounis NG
Clin Chem Lab Med 2016 Oct 1;54(10):1545-59. doi: 10.1515/cclm-2016-0010. PMID: 26966931
Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries.
Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF
Circulation 2015 Mar 10;131(10):861-70. Epub 2015 Jan 13 doi: 10.1161/CIRCULATIONAHA.114.011201. PMID: 25587100

Clinical prediction guides

Epicardial and microvascular coronary artery spasm in biopsy-proven viral myocarditis.
Seitz A, Martínez Pereyra V, Hubert A, Klingel K, Bekeredjian R, Sechtem U, Ong P
Int J Cardiol 2022 Aug 1;360:1-4. Epub 2022 May 6 doi: 10.1016/j.ijcard.2022.05.008. PMID: 35533750
Update on coronary artery spasm 2022 - A narrative review.
Seitz A, Martínez Pereyra V, Sechtem U, Ong P
Int J Cardiol 2022 Jul 15;359:1-6. Epub 2022 Apr 14 doi: 10.1016/j.ijcard.2022.04.011. PMID: 35429510
Vasospastic angina: A literature review of current evidence.
Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O
Arch Cardiovasc Dis 2019 Jan;112(1):44-55. Epub 2018 Sep 7 doi: 10.1016/j.acvd.2018.08.002. PMID: 30197243
Coronary artery spasm: review and update.
Hung MJ, Hu P, Hung MY
Int J Med Sci 2014;11(11):1161-71. Epub 2014 Aug 28 doi: 10.7150/ijms.9623. PMID: 25249785Free PMC Article
Coronary artery spasm.
Conti CR
J Card Surg 1987 Mar;2(1):57-63. doi: 10.1111/j.1540-8191.1987.tb00173.x. PMID: 2979962

Recent systematic reviews

Effect of Statins on Clinical Outcomes in Patients With Coronary Artery Spasm: A Meta-Analysis.
Qilin L, Yanbin Z, Dayong D, Yang L, Huaizhi L, Tao Z, Miao Y, Yi X, Yuntian L
Clin Ther 2022 Jul;44(7):971-981. Epub 2022 Jun 15 doi: 10.1016/j.clinthera.2022.05.007. PMID: 35715362
Safety of intracoronary provocative testing for the diagnosis of coronary artery spasm.
Ciliberti G, Seshasai SRK, Ambrosio G, Kaski JC
Int J Cardiol 2017 Oct 1;244:77-83. Epub 2017 Jun 1 doi: 10.1016/j.ijcard.2017.05.109. PMID: 28622945
Takotsubo cardiomyopathy systematic review: Pathophysiologic process, clinical presentation and diagnostic approach to Takotsubo cardiomyopathy.
Ono R, Falcão LM
Int J Cardiol 2016 Apr 15;209:196-205. Epub 2016 Feb 3 doi: 10.1016/j.ijcard.2016.02.012. PMID: 26896623
Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries.
Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF
Circulation 2015 Mar 10;131(10):861-70. Epub 2015 Jan 13 doi: 10.1161/CIRCULATIONAHA.114.011201. PMID: 25587100
Eosinophilia and coronary artery vasospasm.
Wong CW, Luis S, Zeng I, Stewart RA
Heart Lung Circ 2008 Dec;17(6):488-96. Epub 2008 Aug 21 doi: 10.1016/j.hlc.2008.06.003. PMID: 18718813

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