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Small bowel Crohn disease

MedGen UID:
57617
•Concept ID:
C0156146
•
Disease or Syndrome
Synonyms: Crohn Disease of Small Intestine; Crohn disease of small intestine; Crohn's Disease of Small Intestine; Crohn's disease of small intestine; Crohn's regional enteritis; Crohns disease, small intestine; Granulomatous enteritis; RE - regional enteritis; Regional enteritis; Regional enteritis of small intestine; Regional ileitis of small intestine; Segmental ileitis of small intestine; small bowel Crohn disease; small bowel Crohn's disease
SNOMED CT: Crohn disease of small intestine (56689002); Crohns disease, small intestine (56689002); Granulomatous enteritis (56689002); Regional enteritis (56689002); RE - regional enteritis (56689002); Crohn's regional enteritis (56689002); Crohn's disease of small intestine (56689002); Regional enteritis of small intestine (56689002); Regional ileitis of small intestine (56689002); Segmental ileitis of small intestine (56689002)
 
Monarch Initiative: MONDO:0005539

Definition

Crohn''s disease affecting the small intestine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall bowel Crohn disease

Professional guidelines

PubMed

Enteroscopy in the diagnosis and management of Crohn disease.
Pasha SF, Leighton JA
Gastrointest Endosc Clin N Am 2009 Jul;19(3):427-44. doi: 10.1016/j.giec.2009.04.004. PMID: 19647650

Recent clinical studies

Etiology

Machine Learning Diagnosis of Small-Bowel Crohn Disease Using T2-Weighted MRI Radiomic and Clinical Data.
Liu RX, Li H, Towbin AJ, Ata NA, Smith EA, Tkach JA, Denson LA, He L, Dillman JR
AJR Am J Roentgenol 2024 Jan;222(1):e2329812. Epub 2023 Aug 2 doi: 10.2214/AJR.23.29812. PMID: 37530398
Morphometric Changes in Children With Small Bowel Crohn Disease During Induction of Therapy: A Pilot Study.
Steien DB, Dillman JR, Lopez MJ, Ehrlich P, Adler J
J Pediatr Gastroenterol Nutr 2021 Apr 1;72(4):603-609. doi: 10.1097/MPG.0000000000003009. PMID: 33264183
Capsule Endoscopy and Small Bowel Enteroscopy: Have They Rendered the Radiologist Obsolete?
Ou G, Enns R
Gastrointest Endosc Clin N Am 2019 Jul;29(3):471-485. Epub 2019 Apr 6 doi: 10.1016/j.giec.2019.02.007. PMID: 31078248
Pediatric Small Bowel Crohn Disease: Correlation of US and MR Enterography.
Dillman JR, Smith EA, Sanchez RJ, DiPietro MA, DeMatos-Maillard V, Strouse PJ, Darge K
Radiographics 2015 May-Jun;35(3):835-48. Epub 2015 Apr 3 doi: 10.1148/rg.2015140002. PMID: 25839736Free PMC Article
Surgical treatment of complex small bowel Crohn disease.
Michelassi F, Sultan S
Ann Surg 2014 Aug;260(2):230-5. doi: 10.1097/SLA.0000000000000697. PMID: 24743631

Diagnosis

Machine Learning Diagnosis of Small-Bowel Crohn Disease Using T2-Weighted MRI Radiomic and Clinical Data.
Liu RX, Li H, Towbin AJ, Ata NA, Smith EA, Tkach JA, Denson LA, He L, Dillman JR
AJR Am J Roentgenol 2024 Jan;222(1):e2329812. Epub 2023 Aug 2 doi: 10.2214/AJR.23.29812. PMID: 37530398
Is Fecal Calprotectin a Useful Marker for Small Bowel Crohn Disease?
D'Arcangelo G, Imondi C, Terrin G, Catassi G, Aloi M
J Pediatr Gastroenterol Nutr 2021 Aug 1;73(2):242-246. doi: 10.1097/MPG.0000000000003151. PMID: 33872293
Capsule Endoscopy and Small Bowel Enteroscopy: Have They Rendered the Radiologist Obsolete?
Ou G, Enns R
Gastrointest Endosc Clin N Am 2019 Jul;29(3):471-485. Epub 2019 Apr 6 doi: 10.1016/j.giec.2019.02.007. PMID: 31078248
Pediatric Small Bowel Crohn Disease: Correlation of US and MR Enterography.
Dillman JR, Smith EA, Sanchez RJ, DiPietro MA, DeMatos-Maillard V, Strouse PJ, Darge K
Radiographics 2015 May-Jun;35(3):835-48. Epub 2015 Apr 3 doi: 10.1148/rg.2015140002. PMID: 25839736Free PMC Article
MR enterographic manifestations of small bowel Crohn disease.
Tolan DJ, Greenhalgh R, Zealley IA, Halligan S, Taylor SA
Radiographics 2010 Mar;30(2):367-84. doi: 10.1148/rg.302095028. PMID: 20228323

Therapy

Single-balloon Enteroscopy for Evaluation of Small Bowel Crohn Disease Strictures: Peripheral Blood Lymphocytes As a Risk Factor for Strictures.
Zhang J, Qian X, Yan W, Diao Y, Da B, Shen J, Wang Z, Zhu W
Surg Laparosc Endosc Percutan Tech 2022 Dec 1;32(6):741-746. doi: 10.1097/SLE.0000000000001117. PMID: 36468898
Small-Bowel Crohn Disease Treated With Anti-Tumor Necrosis Factor-α Therapy: MR Enterography Score Changes After 1 Year Predict Long-Term Outcomes.
Gallego JC, de Juan C, Echarri A, Lopez-de-Ullibarri I
AJR Am J Roentgenol 2019 Dec;213(6):1240-1246. Epub 2019 Aug 15 doi: 10.2214/AJR.19.21186. PMID: 31414894
A Diagnostic Accuracy Meta-analysis of CT and MRI for the Evaluation of Small Bowel Crohn Disease.
Liu W, Liu J, Xiao W, Luo G
Acad Radiol 2017 Oct;24(10):1216-1225. Epub 2017 Jun 5 doi: 10.1016/j.acra.2017.04.013. PMID: 28595876
Defining the ultrasound longitudinal natural history of newly diagnosed pediatric small bowel Crohn disease treated with infliximab and infliximab-azathioprine combination therapy.
Dillman JR, Dehkordy SF, Smith EA, DiPietro MA, Sanchez R, DeMatos-Maillard V, Adler J, Zhang B, Trout AT
Pediatr Radiol 2017 Jul;47(8):924-934. Epub 2017 Apr 18 doi: 10.1007/s00247-017-3848-3. PMID: 28421251Free PMC Article
Computed tomography enteroclysis in the diagnosis of intestinal diseases.
Engin G
J Comput Assist Tomogr 2008 Jan-Feb;32(1):9-16. doi: 10.1097/rct.0b013e318059bed7. PMID: 18303282

Prognosis

Machine Learning Diagnosis of Small-Bowel Crohn Disease Using T2-Weighted MRI Radiomic and Clinical Data.
Liu RX, Li H, Towbin AJ, Ata NA, Smith EA, Tkach JA, Denson LA, He L, Dillman JR
AJR Am J Roentgenol 2024 Jan;222(1):e2329812. Epub 2023 Aug 2 doi: 10.2214/AJR.23.29812. PMID: 37530398
Single-balloon Enteroscopy for Evaluation of Small Bowel Crohn Disease Strictures: Peripheral Blood Lymphocytes As a Risk Factor for Strictures.
Zhang J, Qian X, Yan W, Diao Y, Da B, Shen J, Wang Z, Zhu W
Surg Laparosc Endosc Percutan Tech 2022 Dec 1;32(6):741-746. doi: 10.1097/SLE.0000000000001117. PMID: 36468898
Is Fecal Calprotectin a Useful Marker for Small Bowel Crohn Disease?
D'Arcangelo G, Imondi C, Terrin G, Catassi G, Aloi M
J Pediatr Gastroenterol Nutr 2021 Aug 1;73(2):242-246. doi: 10.1097/MPG.0000000000003151. PMID: 33872293
Morphometric Changes in Children With Small Bowel Crohn Disease During Induction of Therapy: A Pilot Study.
Steien DB, Dillman JR, Lopez MJ, Ehrlich P, Adler J
J Pediatr Gastroenterol Nutr 2021 Apr 1;72(4):603-609. doi: 10.1097/MPG.0000000000003009. PMID: 33264183
Small-Bowel Crohn Disease Treated With Anti-Tumor Necrosis Factor-α Therapy: MR Enterography Score Changes After 1 Year Predict Long-Term Outcomes.
Gallego JC, de Juan C, Echarri A, Lopez-de-Ullibarri I
AJR Am J Roentgenol 2019 Dec;213(6):1240-1246. Epub 2019 Aug 15 doi: 10.2214/AJR.19.21186. PMID: 31414894

Clinical prediction guides

Machine Learning Diagnosis of Small-Bowel Crohn Disease Using T2-Weighted MRI Radiomic and Clinical Data.
Liu RX, Li H, Towbin AJ, Ata NA, Smith EA, Tkach JA, Denson LA, He L, Dillman JR
AJR Am J Roentgenol 2024 Jan;222(1):e2329812. Epub 2023 Aug 2 doi: 10.2214/AJR.23.29812. PMID: 37530398
The Simplified MR Index of Activity Score in Pediatric Small-Bowel Crohn Disease: An Interreader Agreement and Responsiveness Study.
Dillman JR, Ata NA, Towbin AJ, Anton CG, Smith EA, Zhang B, Imbus R, Tkach JA, Denson LA
AJR Am J Roentgenol 2023 Jan;220(1):126-133. Epub 2022 Aug 10 doi: 10.2214/AJR.22.28123. PMID: 35946860Free PMC Article
Ultrasound shear wave elastography in pediatric stricturing small bowel Crohn disease: correlation with histology and second harmonic imaging microscopy.
Abu-Ata N, Dillman JR, Rubin JM, Collins MH, Johnson LA, Imbus RS, Bonkowski EL, Denson LA, Higgins PDR
Pediatr Radiol 2023 Jan;53(1):34-45. Epub 2022 Jul 30 doi: 10.1007/s00247-022-05446-z. PMID: 35906430Free PMC Article
Is Fecal Calprotectin a Useful Marker for Small Bowel Crohn Disease?
D'Arcangelo G, Imondi C, Terrin G, Catassi G, Aloi M
J Pediatr Gastroenterol Nutr 2021 Aug 1;73(2):242-246. doi: 10.1097/MPG.0000000000003151. PMID: 33872293
Morphometric Changes in Children With Small Bowel Crohn Disease During Induction of Therapy: A Pilot Study.
Steien DB, Dillman JR, Lopez MJ, Ehrlich P, Adler J
J Pediatr Gastroenterol Nutr 2021 Apr 1;72(4):603-609. doi: 10.1097/MPG.0000000000003009. PMID: 33264183

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