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Mucormycosis

MedGen UID:
7736
•Concept ID:
C0026718
•
Disease or Syndrome
Synonyms: Infection, Mucorales; Mucorales Infection; Mucorales Infections; Mucormycose; Mucormycoses
SNOMED CT: Mucormycosis (76627001)

Definition

Infection in humans and animals caused by any fungus in the order MUCORALES (e.g., RHIZOPUS; MUCOR; CUNNINGHAMELLA; APOPHYSOMYCES; ABSIDIA; SAKSENAEA and RHIZOMUCOR) There are many clinical types associated with infection including central nervous system, lung, gastrointestinal tract, skin, orbit and paranasal sinuses. In humans, it usually occurs as an OPPORTUNISTIC INFECTION. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucormycosis

Professional guidelines

PubMed

Mucormycosis in 2023: an update on pathogenesis and management.
Alqarihi A, Kontoyiannis DP, Ibrahim AS
Front Cell Infect Microbiol 2023;13:1254919. Epub 2023 Sep 21 doi: 10.3389/fcimb.2023.1254919. PMID: 37808914Free PMC Article
Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium.
Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E, Hochhegger B, Hoenigl M, Jensen HE, Lagrou K, Lewis RE, Mellinghoff SC, Mer M, Pana ZD, Seidel D, Sheppard DC, Wahba R, Akova M, Alanio A, Al-Hatmi AMS, Arikan-Akdagli S, Badali H, Ben-Ami R, Bonifaz A, Bretagne S, Castagnola E, Chayakulkeeree M, Colombo AL, Corzo-León DE, Drgona L, Groll AH, Guinea J, Heussel CP, Ibrahim AS, Kanj SS, Klimko N, Lackner M, Lamoth F, Lanternier F, Lass-Floerl C, Lee DG, Lehrnbecher T, Lmimouni BE, Mares M, Maschmeyer G, Meis JF, Meletiadis J, Morrissey CO, Nucci M, Oladele R, Pagano L, Pasqualotto A, Patel A, Racil Z, Richardson M, Roilides E, Ruhnke M, Seyedmousavi S, Sidharthan N, Singh N, Sinko J, Skiada A, Slavin M, Soman R, Spellberg B, Steinbach W, Tan BH, Ullmann AJ, Vehreschild JJ, Vehreschild MJGT, Walsh TJ, White PL, Wiederhold NP, Zaoutis T, Chakrabarti A; Mucormycosis ECMM MSG Global Guideline Writing Group
Lancet Infect Dis 2019 Dec;19(12):e405-e421. Epub 2019 Nov 5 doi: 10.1016/S1473-3099(19)30312-3. PMID: 31699664Free PMC Article
Challenges in the diagnosis and treatment of mucormycosis.
Skiada A, Lass-Floerl C, Klimko N, Ibrahim A, Roilides E, Petrikkos G
Med Mycol 2018 Apr 1;56(suppl_1):93-101. doi: 10.1093/mmy/myx101. PMID: 29538730Free PMC Article

Recent clinical studies

Etiology

COVID-19-associated mucormycosis: a systematic review and meta-analysis of 958 cases.
Özbek L, Topçu U, Manay M, Esen BH, Bektas SN, Aydın S, Özdemir B, Khostelidi SN, Klimko N, Cornely O, Zakhour J, Kanj SS, Seidel D, Hoenigl M, Ergönül Ö
Clin Microbiol Infect 2023 Jun;29(6):722-731. Epub 2023 Mar 13 doi: 10.1016/j.cmi.2023.03.008. PMID: 36921716Free PMC Article
Mucormycosis.
Steinbrink JM, Miceli MH
Infect Dis Clin North Am 2021 Jun;35(2):435-452. doi: 10.1016/j.idc.2021.03.009. PMID: 34016285Free PMC Article
Mucormycosis.
Reid G, Lynch JP 3rd, Fishbein MC, Clark NM
Semin Respir Crit Care Med 2020 Feb;41(1):99-114. Epub 2020 Jan 30 doi: 10.1055/s-0039-3401992. PMID: 32000287
The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports.
Jeong W, Keighley C, Wolfe R, Lee WL, Slavin MA, Kong DCM, Chen SC
Clin Microbiol Infect 2019 Jan;25(1):26-34. Epub 2018 Jul 21 doi: 10.1016/j.cmi.2018.07.011. PMID: 30036666
Epidemiology and clinical manifestations of mucormycosis.
Petrikkos G, Skiada A, Lortholary O, Roilides E, Walsh TJ, Kontoyiannis DP
Clin Infect Dis 2012 Feb;54 Suppl 1:S23-34. doi: 10.1093/cid/cir866. PMID: 22247442

Diagnosis

Rhino-orbital mucormycosis.
Ryu BU, Laylani NAR, Davila-Siliezar P, Lee AG
Curr Opin Ophthalmol 2022 Nov 1;33(6):501-506. Epub 2022 Aug 24 doi: 10.1097/ICU.0000000000000892. PMID: 36066372
Et tu Mucor?
Khatri A, Prasai G, Pandey M, Kharel M, Bohara D, Panthi M
Nepal J Ophthalmol 2021 Jul;13(24):177-185. doi: 10.3126/nepjoph.v13i2.39751. PMID: 35996792
Mucormycosis.
Steinbrink JM, Miceli MH
Infect Dis Clin North Am 2021 Jun;35(2):435-452. doi: 10.1016/j.idc.2021.03.009. PMID: 34016285Free PMC Article
Challenges in the diagnosis and treatment of mucormycosis.
Skiada A, Lass-Floerl C, Klimko N, Ibrahim A, Roilides E, Petrikkos G
Med Mycol 2018 Apr 1;56(suppl_1):93-101. doi: 10.1093/mmy/myx101. PMID: 29538730Free PMC Article
Cutaneous mucormycosis.
Castrejón-Pérez AD, Welsh EC, Miranda I, Ocampo-Candiani J, Welsh O
An Bras Dermatol 2017 May-Jun;92(3):304-311. doi: 10.1590/abd1806-4841.20176614. PMID: 29186239Free PMC Article

Therapy

Mucormycosis in 2023: an update on pathogenesis and management.
Alqarihi A, Kontoyiannis DP, Ibrahim AS
Front Cell Infect Microbiol 2023;13:1254919. Epub 2023 Sep 21 doi: 10.3389/fcimb.2023.1254919. PMID: 37808914Free PMC Article
Efficacy and safety of isavuconazole against deep-seated mycoses: A phase 3, randomized, open-label study in Japan.
Kohno S, Izumikawa K, Takazono T, Miyazaki T, Yoshida M, Kamei K, Ogawa K, Taniguchi S, Akashi K, Tateda K, Mukae H, Miyazaki Y, Okada F, Kanda Y, Kakeya H, Suzuki J, Kimura SI, Kishida M, Matsuda M, Niki Y
J Infect Chemother 2023 Feb;29(2):163-170. Epub 2022 Oct 25 doi: 10.1016/j.jiac.2022.10.010. PMID: 36307059
Mucormycosis.
Reid G, Lynch JP 3rd, Fishbein MC, Clark NM
Semin Respir Crit Care Med 2020 Feb;41(1):99-114. Epub 2020 Jan 30 doi: 10.1055/s-0039-3401992. PMID: 32000287
ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients.
Tissot F, Agrawal S, Pagano L, Petrikkos G, Groll AH, Skiada A, Lass-Flörl C, Calandra T, Viscoli C, Herbrecht R
Haematologica 2017 Mar;102(3):433-444. Epub 2016 Dec 23 doi: 10.3324/haematol.2016.152900. PMID: 28011902Free PMC Article
Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case-control analysis.
Marty FM, Ostrosky-Zeichner L, Cornely OA, Mullane KM, Perfect JR, Thompson GR 3rd, Alangaden GJ, Brown JM, Fredricks DN, Heinz WJ, Herbrecht R, Klimko N, Klyasova G, Maertens JA, Melinkeri SR, Oren I, Pappas PG, Ráčil Z, Rahav G, Santos R, Schwartz S, Vehreschild JJ, Young JH, Chetchotisakd P, Jaruratanasirikul S, Kanj SS, Engelhardt M, Kaufhold A, Ito M, Lee M, Sasse C, Maher RM, Zeiher B, Vehreschild MJGT; VITAL and FungiScope Mucormycosis Investigators
Lancet Infect Dis 2016 Jul;16(7):828-837. Epub 2016 Mar 9 doi: 10.1016/S1473-3099(16)00071-2. PMID: 26969258

Prognosis

Pulmonary Mucormycosis.
Mejia Buritica L, Karduss Urueta AJ
N Engl J Med 2021 May 6;384(18):e69. Epub 2021 May 1 doi: 10.1056/NEJMicm2030205. PMID: 33951358
Rhino-orbital-cerebral mucormycosis.
Chen IW, Lin CW
CMAJ 2019 Apr 23;191(16):E450. doi: 10.1503/cmaj.181210. PMID: 31015350Free PMC Article
Cutaneous mucormycosis.
Vulsteke JB, Deeren D
Transpl Infect Dis 2019 Apr;21(2):e13039. Epub 2019 Jan 4 doi: 10.1111/tid.13039. PMID: 30548761
Palatal Mucormycosis.
Brondfield S, Kaplan L, Dhaliwal G
J Gen Intern Med 2018 Oct;33(10):1815. Epub 2018 May 9 doi: 10.1007/s11606-018-4481-z. PMID: 30088205Free PMC Article
Mucormycosis in Iran: a systematic review.
Vaezi A, Moazeni M, Rahimi MT, de Hoog S, Badali H
Mycoses 2016 Jul;59(7):402-15. Epub 2016 Feb 15 doi: 10.1111/myc.12474. PMID: 26906121

Clinical prediction guides

The changing epidemiology of fungal infections.
Lass-Flörl C, Steixner S
Mol Aspects Med 2023 Dec;94:101215. Epub 2023 Oct 5 doi: 10.1016/j.mam.2023.101215. PMID: 37804792
COVID-19-associated mucormycosis: a systematic review and meta-analysis of 958 cases.
Özbek L, Topçu U, Manay M, Esen BH, Bektas SN, Aydın S, Özdemir B, Khostelidi SN, Klimko N, Cornely O, Zakhour J, Kanj SS, Seidel D, Hoenigl M, Ergönül Ö
Clin Microbiol Infect 2023 Jun;29(6):722-731. Epub 2023 Mar 13 doi: 10.1016/j.cmi.2023.03.008. PMID: 36921716Free PMC Article
New Perspectives on Antimicrobial Agents: Isavuconazole.
Lewis JS 2nd, Wiederhold NP, Hakki M, Thompson GR 3rd
Antimicrob Agents Chemother 2022 Sep 20;66(9):e0017722. Epub 2022 Aug 15 doi: 10.1128/aac.00177-22. PMID: 35969068Free PMC Article
COVID-19 and Eye: A Review of Ophthalmic Manifestations of COVID-19.
Sen M, Honavar SG, Sharma N, Sachdev MS
Indian J Ophthalmol 2021 Mar;69(3):488-509. doi: 10.4103/ijo.IJO_297_21. PMID: 33595463Free PMC Article
The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports.
Jeong W, Keighley C, Wolfe R, Lee WL, Slavin MA, Kong DCM, Chen SC
Clin Microbiol Infect 2019 Jan;25(1):26-34. Epub 2018 Jul 21 doi: 10.1016/j.cmi.2018.07.011. PMID: 30036666

Recent systematic reviews

COVID-19-associated mucormycosis: a systematic review and meta-analysis of 958 cases.
Özbek L, Topçu U, Manay M, Esen BH, Bektas SN, Aydın S, Özdemir B, Khostelidi SN, Klimko N, Cornely O, Zakhour J, Kanj SS, Seidel D, Hoenigl M, Ergönül Ö
Clin Microbiol Infect 2023 Jun;29(6):722-731. Epub 2023 Mar 13 doi: 10.1016/j.cmi.2023.03.008. PMID: 36921716Free PMC Article
Mucormycosis threats: A systemic review.
Prakash S, Kumar A
J Basic Microbiol 2023 Feb;63(2):119-127. Epub 2022 Nov 4 doi: 10.1002/jobm.202200334. PMID: 36333107
Mucormycosis following burn injuries: A systematic review.
Dang J, Goel P, Choi KJ, Massenzio E, Landau MJ, Pham CH, Huang S, Yenikomshian HA, Spellberg B, Gillenwater TJ
Burns 2023 Feb;49(1):15-25. Epub 2022 May 13 doi: 10.1016/j.burns.2022.05.012. PMID: 35842270
Rhino-orbital-cerebral-mucormycosis in COVID-19: A systematic review.
Bhattacharyya A, Sarma P, Sharma DJ, Das KK, Kaur H, Prajapat M, Kumar S, Bansal S, Prakash A, Avti P, Thota P, Reddy DH, Gautam BS, Medhi B
Indian J Pharmacol 2021 Jul-Aug;53(4):317-327. doi: 10.4103/ijp.ijp_419_21. PMID: 34414911Free PMC Article
The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports.
Jeong W, Keighley C, Wolfe R, Lee WL, Slavin MA, Kong DCM, Chen SC
Clin Microbiol Infect 2019 Jan;25(1):26-34. Epub 2018 Jul 21 doi: 10.1016/j.cmi.2018.07.011. PMID: 30036666

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