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Muscle atrophy

MedGen UID:
7754
•Concept ID:
C0026846
•
Pathologic Function
Synonyms: Atrophies, Muscle; Atrophies, Muscular; Atrophy, Muscle; Atrophy, Muscular; Muscle Atrophies; Muscle Atrophy; Muscular Atrophies; Muscular Atrophy
SNOMED CT: Muscle wasting disorder (88092000); Muscle thinning (88092000); Amyotrophia (88092000); Muscle atrophy (88092000); Amyotrophy (88092000); Muscular atrophy (88092000); Muscle wasting (88092000)

Definition

The loss of muscle tissue due to inactivity or disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMuscle atrophy

Professional guidelines

PubMed

Advances and limitations for the treatment of spinal muscular atrophy.
Day JW, Howell K, Place A, Long K, Rossello J, Kertesz N, Nomikos G
BMC Pediatr 2022 Nov 3;22(1):632. doi: 10.1186/s12887-022-03671-x. PMID: 36329412Free PMC Article
Muscle Weakness in Adults: Evaluation and Differential Diagnosis.
Larson ST, Wilbur J
Am Fam Physician 2020 Jan 15;101(2):95-108. PMID: 31939642
Pathogenesis and Management of Sarcopenia.
Dhillon RJ, Hasni S
Clin Geriatr Med 2017 Feb;33(1):17-26. doi: 10.1016/j.cger.2016.08.002. PMID: 27886695Free PMC Article

Recent clinical studies

Etiology

Human skeletal muscle-specific atrophy with aging: a comprehensive review.
Naruse M, Trappe S, Trappe TA
J Appl Physiol (1985) 2023 Apr 1;134(4):900-914. Epub 2023 Feb 24 doi: 10.1152/japplphysiol.00768.2022. PMID: 36825643Free PMC Article
Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions.
Jun L, Robinson M, Geetha T, Broderick TL, Babu JR
Int J Mol Sci 2023 Feb 3;24(3) doi: 10.3390/ijms24032973. PMID: 36769296Free PMC Article
Pathogenesis and Management of Sarcopenia.
Dhillon RJ, Hasni S
Clin Geriatr Med 2017 Feb;33(1):17-26. doi: 10.1016/j.cger.2016.08.002. PMID: 27886695Free PMC Article
Resistance training and sarcopenia.
Giallauria F, Cittadini A, Smart NA, Vigorito C
Monaldi Arch Chest Dis 2016 Jun 22;84(1-2):738. doi: 10.4081/monaldi.2015.738. PMID: 27374049
Muscle type and fiber type specificity in muscle wasting.
Ciciliot S, Rossi AC, Dyar KA, Blaauw B, Schiaffino S
Int J Biochem Cell Biol 2013 Oct;45(10):2191-9. Epub 2013 May 21 doi: 10.1016/j.biocel.2013.05.016. PMID: 23702032

Diagnosis

Metabolomics in rheumatoid arthritis: Advances and review.
Xu L, Chang C, Jiang P, Wei K, Zhang R, Jin Y, Zhao J, Xu L, Shi Y, Guo S, He D
Front Immunol 2022;13:961708. Epub 2022 Aug 11 doi: 10.3389/fimmu.2022.961708. PMID: 36032122Free PMC Article
MOTS-c reduces myostatin and muscle atrophy signaling.
Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim SJ
Am J Physiol Endocrinol Metab 2021 Apr 1;320(4):E680-E690. Epub 2021 Feb 8 doi: 10.1152/ajpendo.00275.2020. PMID: 33554779Free PMC Article
Intensive care unit-acquired weakness: unanswered questions and targets for future research.
Piva S, Fagoni N, Latronico N
F1000Res 2019;8 Epub 2019 Apr 17 doi: 10.12688/f1000research.17376.1. PMID: 31069055Free PMC Article
Pathogenesis and Management of Sarcopenia.
Dhillon RJ, Hasni S
Clin Geriatr Med 2017 Feb;33(1):17-26. doi: 10.1016/j.cger.2016.08.002. PMID: 27886695Free PMC Article
False localising signs.
Larner AJ
J Neurol Neurosurg Psychiatry 2003 Apr;74(4):415-8. doi: 10.1136/jnnp.74.4.415. PMID: 12640051Free PMC Article

Therapy

Blood Flow Restriction Therapy Preserves Lower Extremity Bone and Muscle Mass After ACL Reconstruction.
Jack RA 2nd, Lambert BS, Hedt CA, Delgado D, Goble H, McCulloch PC
Sports Health 2023 May;15(3):361-371. Epub 2022 Jun 27 doi: 10.1177/19417381221101006. PMID: 35762124Free PMC Article
Advances and limitations for the treatment of spinal muscular atrophy.
Day JW, Howell K, Place A, Long K, Rossello J, Kertesz N, Nomikos G
BMC Pediatr 2022 Nov 3;22(1):632. doi: 10.1186/s12887-022-03671-x. PMID: 36329412Free PMC Article
Utility of Neuromuscular Electrical Stimulation to Preserve Quadriceps Muscle Fiber Size and Contractility After Anterior Cruciate Ligament Injuries and Reconstruction: A Randomized, Sham-Controlled, Blinded Trial.
Toth MJ, Tourville TW, Voigt TB, Choquette RH, Anair BM, Falcone MJ, Failla MJ, Stevens-Lapslaey JE, Endres NK, Slauterbeck JR, Beynnon BD
Am J Sports Med 2020 Aug;48(10):2429-2437. Epub 2020 Jul 6 doi: 10.1177/0363546520933622. PMID: 32631074Free PMC Article
Amelioration of muscle wasting by glucagon-like peptide-1 receptor agonist in muscle atrophy.
Hong Y, Lee JH, Jeong KW, Choi CS, Jun HS
J Cachexia Sarcopenia Muscle 2019 Aug;10(4):903-918. Epub 2019 Apr 24 doi: 10.1002/jcsm.12434. PMID: 31020810Free PMC Article
Glucocorticoid-induced skeletal muscle atrophy.
Schakman O, Kalista S, Barbé C, Loumaye A, Thissen JP
Int J Biochem Cell Biol 2013 Oct;45(10):2163-72. Epub 2013 Jun 24 doi: 10.1016/j.biocel.2013.05.036. PMID: 23806868

Prognosis

Metabolomics in rheumatoid arthritis: Advances and review.
Xu L, Chang C, Jiang P, Wei K, Zhang R, Jin Y, Zhao J, Xu L, Shi Y, Guo S, He D
Front Immunol 2022;13:961708. Epub 2022 Aug 11 doi: 10.3389/fimmu.2022.961708. PMID: 36032122Free PMC Article
Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia.
Ito A, Hashimoto M, Tanihata J, Matsubayashi S, Sasaki R, Fujimoto S, Kawamoto H, Hosaka Y, Ichikawa A, Kadota T, Fujita Y, Takekoshi D, Ito S, Minagawa S, Numata T, Hara H, Matsuoka T, Udaka J, Araya J, Saito M, Kuwano K
J Cachexia Sarcopenia Muscle 2022 Jun;13(3):1864-1882. Epub 2022 Apr 3 doi: 10.1002/jcsm.12988. PMID: 35373498Free PMC Article
Clinical review: intensive care unit acquired weakness.
Hermans G, Van den Berghe G
Crit Care 2015 Aug 5;19(1):274. doi: 10.1186/s13054-015-0993-7. PMID: 26242743Free PMC Article
Ghrelin: much more than a hunger hormone.
Pradhan G, Samson SL, Sun Y
Curr Opin Clin Nutr Metab Care 2013 Nov;16(6):619-24. doi: 10.1097/MCO.0b013e328365b9be. PMID: 24100676Free PMC Article
Cellular and molecular mechanisms of muscle atrophy.
Bonaldo P, Sandri M
Dis Model Mech 2013 Jan;6(1):25-39. doi: 10.1242/dmm.010389. PMID: 23268536Free PMC Article

Clinical prediction guides

Monotropein Improves Dexamethasone-Induced Muscle Atrophy via the AKT/mTOR/FOXO3a Signaling Pathways.
Wang P, Kang SY, Kim SJ, Park YK, Jung HW
Nutrients 2022 Apr 29;14(9) doi: 10.3390/nu14091859. PMID: 35565825Free PMC Article
Botulinum Toxin in the Management of Children with Cerebral Palsy.
Multani I, Manji J, Hastings-Ison T, Khot A, Graham K
Paediatr Drugs 2019 Aug;21(4):261-281. doi: 10.1007/s40272-019-00344-8. PMID: 31257556Free PMC Article
Intensive care unit-acquired weakness: unanswered questions and targets for future research.
Piva S, Fagoni N, Latronico N
F1000Res 2019;8 Epub 2019 Apr 17 doi: 10.12688/f1000research.17376.1. PMID: 31069055Free PMC Article
Skeletal muscle atrophy during short-term disuse: implications for age-related sarcopenia.
Wall BT, Dirks ML, van Loon LJ
Ageing Res Rev 2013 Sep;12(4):898-906. Epub 2013 Aug 12 doi: 10.1016/j.arr.2013.07.003. PMID: 23948422
Glucocorticoid-induced skeletal muscle atrophy.
Schakman O, Kalista S, Barbé C, Loumaye A, Thissen JP
Int J Biochem Cell Biol 2013 Oct;45(10):2163-72. Epub 2013 Jun 24 doi: 10.1016/j.biocel.2013.05.036. PMID: 23806868

Recent systematic reviews

The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis.
Fazzini B, Märkl T, Costas C, Blobner M, Schaller SJ, Prowle J, Puthucheary Z, Wackerhage H
Crit Care 2023 Jan 3;27(1):2. doi: 10.1186/s13054-022-04253-0. PMID: 36597123Free PMC Article
Effects of Blood Flow Restriction Training on Clinical Outcomes for Patients With ACL Reconstruction: A Systematic Review.
Colapietro M, Portnoff B, Miller SJ, Sebastianelli W, Vairo GL
Sports Health 2023 Mar-Apr;15(2):260-273. Epub 2022 Feb 8 doi: 10.1177/19417381211070834. PMID: 35130790Free PMC Article
Biomarkers shared by frailty and sarcopenia in older adults: A systematic review and meta-analysis.
Picca A, Coelho-Junior HJ, Calvani R, Marzetti E, Vetrano DL
Ageing Res Rev 2022 Jan;73:101530. Epub 2021 Nov 25 doi: 10.1016/j.arr.2021.101530. PMID: 34839041
Nonuniform loss of muscle strength and atrophy during bed rest: a systematic review.
Marusic U, Narici M, Simunic B, Pisot R, Ritzmann R
J Appl Physiol (1985) 2021 Jul 1;131(1):194-206. Epub 2021 Mar 11 doi: 10.1152/japplphysiol.00363.2020. PMID: 33703945Free PMC Article
Creatine in Health and Disease.
Kreider RB, Stout JR
Nutrients 2021 Jan 29;13(2) doi: 10.3390/nu13020447. PMID: 33572884Free PMC Article

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