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Arachnoiditis

MedGen UID:
8175
•Concept ID:
C0003708
•
Disease or Syndrome
Synonyms: Arachnoid Membrane Inflammation; Arachnoid Membrane Inflammations; Arachnoiditides; Inflammation, Arachnoid Membrane; Inflammations, Arachnoid Membrane
SNOMED CT: Arachnoiditis (8217007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015304
Orphanet: ORPHA137817

Definition

A chronic inflammation of the arachnoid layer of the meninges, of which adhesive arachnoiditis is the most severe form, characterized by debilitating, intractable neurogenic back and limb pain and a range of other neurological problems. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVArachnoiditis
Follow this link to review classifications for Arachnoiditis in Orphanet.

Professional guidelines

PubMed

Diagnosis and Management of Tuberculous Meningitis in Children- an Update.
van Toorn R, Solomons R
Semin Pediatr Neurol 2023 Oct;47:101071. Epub 2023 Aug 2 doi: 10.1016/j.spen.2023.101071. PMID: 37919031
Subarachnoid neurocysticercosis: emerging concepts and treatment.
Nash TE, O'Connell EM
Curr Opin Infect Dis 2020 Oct;33(5):339-346. doi: 10.1097/QCO.0000000000000669. PMID: 32868512Free PMC Article
Update on the diagnosis and management of tuberculous meningitis in children.
van Toorn R, Solomons R
Semin Pediatr Neurol 2014 Mar;21(1):12-8. Epub 2014 Feb 2 doi: 10.1016/j.spen.2014.01.006. PMID: 24655399

Recent clinical studies

Etiology

Symptomatic secondary spinal arachnoid cysts: a systematic review.
Wang YB, Wang DH, Deng SL
Spine J 2023 Aug;23(8):1199-1211. Epub 2023 Mar 15 doi: 10.1016/j.spinee.2023.03.002. PMID: 36924909
MRI Findings of Arachnoiditis, Revisited. Is Classification Possible?
El Homsi M, Gharzeddine K, Cuevas J, Arevalo-Perez J, Rebeiz K, Khoury NJ, Moukaddam H
J Magn Reson Imaging 2021 Sep;54(3):904-909. Epub 2021 Feb 28 doi: 10.1002/jmri.27583. PMID: 33644967
Neurotuberculosis: an update.
Cherian A, Ajitha KC, Iype T, Divya KP
Acta Neurol Belg 2021 Feb;121(1):11-21. Epub 2021 Jan 5 doi: 10.1007/s13760-020-01575-0. PMID: 33400226
Spinal cord involvement in tuberculous meningitis.
Garg RK, Malhotra HS, Gupta R
Spinal Cord 2015 Sep;53(9):649-57. Epub 2015 Apr 21 doi: 10.1038/sc.2015.58. PMID: 25896347
Infectious complications of regional anesthesia.
Horlocker TT, Wedel DJ
Best Pract Res Clin Anaesthesiol 2008 Sep;22(3):451-75. doi: 10.1016/j.bpa.2008.06.003. PMID: 18831298

Diagnosis

The Global Neurological Burden of Tuberculosis.
Thakur K, Das M, Dooley KE, Gupta A
Semin Neurol 2018 Apr;38(2):226-237. Epub 2018 May 23 doi: 10.1055/s-0038-1651500. PMID: 29791949
Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443
Arachnoiditis.
Kalina J
J Pain Palliat Care Pharmacother 2012 Jun;26(2):176-7. doi: 10.3109/15360288.2012.671239. PMID: 22764866
Tuberculous meningitis.
Leonard JM, Des Prez RM
Infect Dis Clin North Am 1990 Dec;4(4):769-87. PMID: 2277198
Progress in syringomyelia.
Williams B
Neurol Res 1986 Sep;8(3):130-45. doi: 10.1080/01616412.1986.11739745. PMID: 2877406

Therapy

Neurotuberculosis: an update.
Cherian A, Ajitha KC, Iype T, Divya KP
Acta Neurol Belg 2021 Feb;121(1):11-21. Epub 2021 Jan 5 doi: 10.1007/s13760-020-01575-0. PMID: 33400226
Subarachnoid neurocysticercosis: emerging concepts and treatment.
Nash TE, O'Connell EM
Curr Opin Infect Dis 2020 Oct;33(5):339-346. doi: 10.1097/QCO.0000000000000669. PMID: 32868512Free PMC Article
Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443
The postsurgical spine.
Santos Armentia E, Prada González R, Silva Priegue N
Radiologia 2016 Apr;58 Suppl 1:104-14. Epub 2016 Jan 4 doi: 10.1016/j.rx.2015.11.001. PMID: 26767541
Arachnoiditis.
Kalina J
J Pain Palliat Care Pharmacother 2012 Jun;26(2):176-7. doi: 10.3109/15360288.2012.671239. PMID: 22764866

Prognosis

Neuro-ophthalmic manifestations of tuberculosis.
Dhiman R, Lakra S, Panda PK, Hemachandran N, Sharma S, Saxena R
Eye (Lond) 2022 Jan;36(1):15-28. Epub 2021 Jun 14 doi: 10.1038/s41433-021-01619-6. PMID: 34127839Free PMC Article
Subarachnoid neurocysticercosis: emerging concepts and treatment.
Nash TE, O'Connell EM
Curr Opin Infect Dis 2020 Oct;33(5):339-346. doi: 10.1097/QCO.0000000000000669. PMID: 32868512Free PMC Article
Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443
Hydrocephalus in neurocysticercosis.
Matushita H, Pinto FC, Cardeal DD, Teixeira MJ
Childs Nerv Syst 2011 Oct;27(10):1709-21. Epub 2011 Sep 17 doi: 10.1007/s00381-011-1500-3. PMID: 21928035
Tuberculous optochiasmatic arachnoiditis.
Anupriya A, Sunithi M, Maya T, Goel M, Alexander M, Aaron S, Mathew V
Neurol India 2010 Sep-Oct;58(5):732-5. doi: 10.4103/0028-3886.72194. PMID: 21045497

Clinical prediction guides

A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics.
Kumthekar PU, Avram MJ, Lassman AB, Lin NU, Lee E, Grimm SA, Schwartz M, Bell Burdett KL, Lukas RV, Dixit K, Perron I, Zhang H, Gradishar WJ, Pentsova EI, Jeyapalan S, Groves MD, Melisko M, Raizer JJ
Neuro Oncol 2023 Mar 14;25(3):557-565. doi: 10.1093/neuonc/noac195. PMID: 35948282Free PMC Article
Neuro-ophthalmic manifestations of tuberculosis.
Dhiman R, Lakra S, Panda PK, Hemachandran N, Sharma S, Saxena R
Eye (Lond) 2022 Jan;36(1):15-28. Epub 2021 Jun 14 doi: 10.1038/s41433-021-01619-6. PMID: 34127839Free PMC Article
Subarachnoid neurocysticercosis: emerging concepts and treatment.
Nash TE, O'Connell EM
Curr Opin Infect Dis 2020 Oct;33(5):339-346. doi: 10.1097/QCO.0000000000000669. PMID: 32868512Free PMC Article
Spinal cord involvement in tuberculous meningitis.
Garg RK, Malhotra HS, Gupta R
Spinal Cord 2015 Sep;53(9):649-57. Epub 2015 Apr 21 doi: 10.1038/sc.2015.58. PMID: 25896347
Tuberculous optochiasmatic arachnoiditis.
Anupriya A, Sunithi M, Maya T, Goel M, Alexander M, Aaron S, Mathew V
Neurol India 2010 Sep-Oct;58(5):732-5. doi: 10.4103/0028-3886.72194. PMID: 21045497

Recent systematic reviews

Symptomatic secondary spinal arachnoid cysts: a systematic review.
Wang YB, Wang DH, Deng SL
Spine J 2023 Aug;23(8):1199-1211. Epub 2023 Mar 15 doi: 10.1016/j.spinee.2023.03.002. PMID: 36924909
Fourth ventricle to spinal subarachnoid space stenting in pediatric patients with refractory syringomyelia: case series and systematic review.
Spennato P, Vitulli F, Tafuto R, Imperato A, Mirone G, Cinalli G
Neurosurg Rev 2023 Mar 11;46(1):67. doi: 10.1007/s10143-023-01972-y. PMID: 36905420
The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis).
Palackdkharry CS, Wottrich S, Dienes E, Bydon M, Steinmetz MP, Traynelis VC
PLoS One 2022;17(9):e0274634. Epub 2022 Sep 30 doi: 10.1371/journal.pone.0274634. PMID: 36178925Free PMC Article
Management of syringomyelia associated with tuberculous meningitis: A case report and systematic review of the literature.
Kannapadi NV, Alomari SO, Caturegli G, Bydon A, Cho SM
J Clin Neurosci 2021 May;87:20-25. Epub 2021 Mar 5 doi: 10.1016/j.jocn.2021.01.052. PMID: 33863527
Arachnoiditis, a complication of epidural blood patch for the treatment of low-pressure headache: A case report and systematic review.
Villani LA, Digre KB, Cortez MM, Bokat C, Rassner UA, Ozudogru SN
Headache 2021 Feb;61(2):244-252. Epub 2021 Feb 13 doi: 10.1111/head.14076. PMID: 33583044

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