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Lymphocytic colitis

MedGen UID:
98006
•Concept ID:
C0400822
•
Disease or Syndrome
Synonyms: Colitis, Lymphocytic; Lymphocytic Colitis
SNOMED CT: Lymphocytic colitis (1187071008)
 
Monarch Initiative: MONDO:0000704

Definition

Microscopic colitis characterized by the accumulation of lymphocytes in the colonic epithelium and lamina propria. Patients present with chronic watery diarrhea. Colonoscopy reveals normal colonic mucosa. The diagnosis is made with the microscopic examination of the colonic biopsy samples. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphocytic colitis
Follow this link to review classifications for Lymphocytic colitis in Orphanet.

Professional guidelines

PubMed

Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients.
Rojo E, Casanova MJ, Gisbert JP
Rev Esp Enferm Dig 2020 Jan;112(1):53-58. doi: 10.17235/reed.2019.6655/2019. PMID: 31880163
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Diagnosis and Management of Microscopic Colitis.
Pardi DS
Am J Gastroenterol 2017 Jan;112(1):78-85. Epub 2016 Nov 29 doi: 10.1038/ajg.2016.477. PMID: 27897155

Recent clinical studies

Etiology

Microscopic colitis: lymphocytic colitis, collagenous colitis, and beyond.
Yuan L, Wu TT, Zhang L
Hum Pathol 2023 Feb;132:89-101. Epub 2022 Jul 6 doi: 10.1016/j.humpath.2022.06.027. PMID: 35809686
Microscopic Colitis: A Concise Review for Clinicians.
Tome J, Kamboj AK, Pardi DS
Mayo Clin Proc 2021 May;96(5):1302-1308. doi: 10.1016/j.mayocp.2021.03.022. PMID: 33958059
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Microscopic colitis: A review of etiology, treatment and refractory disease.
Park T, Cave D, Marshall C
World J Gastroenterol 2015 Aug 7;21(29):8804-10. doi: 10.3748/wjg.v21.i29.8804. PMID: 26269669Free PMC Article
Microscopic colitis.
Ianiro G, Cammarota G, Valerio L, Annicchiarico BE, Milani A, Siciliano M, Gasbarrini A
World J Gastroenterol 2012 Nov 21;18(43):6206-15. doi: 10.3748/wjg.v18.i43.6206. PMID: 23180940Free PMC Article

Diagnosis

Microscopic colitis: lymphocytic colitis, collagenous colitis, and beyond.
Yuan L, Wu TT, Zhang L
Hum Pathol 2023 Feb;132:89-101. Epub 2022 Jul 6 doi: 10.1016/j.humpath.2022.06.027. PMID: 35809686
Secukinumab-Induced Lymphocytic Colitis.
Gandu SSK, Khan MH, Vasikaran A, Pandit S
J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221110399. doi: 10.1177/23247096221110399. PMID: 35801542Free PMC Article
Microscopic colitis.
Burke KE, D'Amato M, Ng SC, Pardi DS, Ludvigsson JF, Khalili H
Nat Rev Dis Primers 2021 Jun 10;7(1):39. doi: 10.1038/s41572-021-00273-2. PMID: 34112810
Microscopic Colitis: A Concise Review for Clinicians.
Tome J, Kamboj AK, Pardi DS
Mayo Clin Proc 2021 May;96(5):1302-1308. doi: 10.1016/j.mayocp.2021.03.022. PMID: 33958059
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066

Therapy

Secukinumab-Induced Lymphocytic Colitis.
Gandu SSK, Khan MH, Vasikaran A, Pandit S
J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221110399. doi: 10.1177/23247096221110399. PMID: 35801542Free PMC Article
Microscopic colitis.
Burke KE, D'Amato M, Ng SC, Pardi DS, Ludvigsson JF, Khalili H
Nat Rev Dis Primers 2021 Jun 10;7(1):39. doi: 10.1038/s41572-021-00273-2. PMID: 34112810
Microscopic Colitis: A Concise Review for Clinicians.
Tome J, Kamboj AK, Pardi DS
Mayo Clin Proc 2021 May;96(5):1302-1308. doi: 10.1016/j.mayocp.2021.03.022. PMID: 33958059
Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients.
Rojo E, Casanova MJ, Gisbert JP
Rev Esp Enferm Dig 2020 Jan;112(1):53-58. doi: 10.17235/reed.2019.6655/2019. PMID: 31880163
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066

Prognosis

SARS-CoV-2-triggered lymphocytic colitis.
Nassar IO, Langman G, Quraishi MN, Sharma N
BMJ Case Rep 2021 Aug 24;14(8) doi: 10.1136/bcr-2021-243003. PMID: 34429288Free PMC Article
Microscopic Colitis: A Concise Review for Clinicians.
Tome J, Kamboj AK, Pardi DS
Mayo Clin Proc 2021 May;96(5):1302-1308. doi: 10.1016/j.mayocp.2021.03.022. PMID: 33958059
Microscopic colitis: pathophysiology and clinical management.
Miehlke S, Verhaegh B, Tontini GE, Madisch A, Langner C, Münch A
Lancet Gastroenterol Hepatol 2019 Apr;4(4):305-314. doi: 10.1016/S2468-1253(19)30048-2. PMID: 30860066
Microscopic colitis.
Bouma G, Münch A
Dig Dis 2015;33(2):208-214. Epub 2015 Apr 22 doi: 10.1159/000369517. PMID: 25925924
Microscopic colitis.
Pardi DS
Clin Geriatr Med 2014 Feb;30(1):55-65. doi: 10.1016/j.cger.2013.10.005. PMID: 24267602

Clinical prediction guides

Is mastocytic colitis a specific clinical-pathological entity?
Vernia F, Tatti T, Necozione S, Capannolo A, Cesaro N, Magistroni M, Valvano M, Pompili S, Sferra R, Vetuschi A, Latella G
Eur J Histochem 2022 Nov 28;66(4) doi: 10.4081/ejh.2022.3499. PMID: 36440694Free PMC Article
Analysis of Clinical and Histopathological Findings in Microscopic Colitis.
Topel G, Cakir E, Aydin I, Dilek FH, Sari AA
Turk Patoloji Derg 2022;38(3):275-283. doi: 10.5146/tjpath.2022.01574. PMID: 35642347Free PMC Article
Microscopic colitis: A review of etiology, treatment and refractory disease.
Park T, Cave D, Marshall C
World J Gastroenterol 2015 Aug 7;21(29):8804-10. doi: 10.3748/wjg.v21.i29.8804. PMID: 26269669Free PMC Article
Microscopic colitis: a review.
Farrukh A, Mayberry JF
Colorectal Dis 2014 Dec;16(12):957-64. doi: 10.1111/codi.12716. PMID: 25039699
Collagenous and lymphocytic colitis: systematic review and update of the literature.
Temmerman F, Baert F
Dig Dis 2009;27 Suppl 1:137-45. Epub 2010 Mar 4 doi: 10.1159/000268134. PMID: 20203510

Recent systematic reviews

Drug Exposure and Risk of Microscopic Colitis: A Systematic Review and Meta-Analysis.
Zhang SW, Xu RH, Chen D
Dig Dis 2023;41(2):217-226. Epub 2022 Sep 6 doi: 10.1159/000526809. PMID: 36067746
Pathogenesis of Microscopic Colitis: A Systematic Review.
Zabana Y, Tontini G, Hultgren-Hörnquist E, Skonieczna-Żydecka K, Latella G, Østvik AE, Marlicz W, D'Amato M, Arias A, Mielhke S, Münch A, Fernández-Bañares F, Lucendo AJ
J Crohns Colitis 2022 Jan 28;16(1):143-161. doi: 10.1093/ecco-jcc/jjab123. PMID: 34272945
Irritable Bowel Syndrome and Microscopic Colitis: A Systematic Review and Meta-analysis.
Kamp EJ, Kane JS, Ford AC
Clin Gastroenterol Hepatol 2016 May;14(5):659-68.e1; quiz e54-5. Epub 2015 Nov 19 doi: 10.1016/j.cgh.2015.09.031. PMID: 26453949
Collagenous and lymphocytic colitis: systematic review and update of the literature.
Temmerman F, Baert F
Dig Dis 2009;27 Suppl 1:137-45. Epub 2010 Mar 4 doi: 10.1159/000268134. PMID: 20203510
Systematic review: microscopic colitis.
Nyhlin N, Bohr J, Eriksson S, Tysk C
Aliment Pharmacol Ther 2006 Jun 1;23(11):1525-34. doi: 10.1111/j.1365-2036.2006.02913.x. PMID: 16696800

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