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Malignant neoplasm of body of uterus

MedGen UID:
56311
•Concept ID:
C0153574
•
Neoplastic Process
Synonyms: Body of uterus Ca; Malignant Corpus Uteri Neoplasm; Malignant Corpus Uteri Tumor; Malignant Neoplasm of the Uterine Body; Malignant Neoplasm of Uterine Body; Malignant tumor of body of uterus; Malignant Tumor of the Uterine Body; Malignant Tumor of Uterine Body; Malignant Uterine Body Neoplasm; Malignant Uterine Body Tumor; Malignant Uterine Corpus Neoplasm; Malignant Uterine Corpus Tumor
SNOMED CT: Malignant neoplasm of body of uterus (371972005); Malignant tumor of body of uterus (371972005); Body of uterus Ca (371972005)

Definition

A malignant neoplasm that affects the uterine corpus. Representative examples include endometrial carcinoma, carcinosarcoma, leiomyosarcoma, and adenosarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Malignant neoplasm of body of uterus

Professional guidelines

PubMed

ACR Appropriateness Criteria® Fibroids.
Expert Panel on GYN and OB Imaging, Ascher SM, Wasnik AP, Robbins JB, Adelman M, Brook OR, Feldman MK, Jones LP, Knavel Koepsel EM, Patel-Lippmann KK, Patlas MN, VanBuren W, Maturen KE
J Am Coll Radiol 2022 Nov;19(11S):S319-S328. doi: 10.1016/j.jacr.2022.09.019. PMID: 36436959
Management of stage I and II cervical cancer: a review.
Chou B, Prasad Venkatesulu B, Coleman RL, Harkenrider M, Small W Jr
Int J Gynecol Cancer 2022 Mar;32(3):216-224. doi: 10.1136/ijgc-2021-002527. PMID: 35256406
Consensus statement on the use of gonadotropin-releasing hormone analogs in children.
Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR; ESPE-LWPES GnRH Analogs Consensus Conference Group, Antoniazzi F, Berenbaum S, Bourguignon JP, Chrousos GP, Coste J, Deal S, de Vries L, Foster C, Heger S, Holland J, Jahnukainen K, Juul A, Kaplowitz P, Lahlou N, Lee MM, Lee P, Merke DP, Neely EK, Oostdijk W, Phillip M, Rosenfield RL, Shulman D, Styne D, Tauber M, Wit JM
Pediatrics 2009 Apr;123(4):e752-62. Epub 2009 Mar 30 doi: 10.1542/peds.2008-1783. PMID: 19332438

Recent clinical studies

Etiology

Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
Autophagy in the physiological endometrium and cancer.
Devis-Jauregui L, Eritja N, Davis ML, Matias-Guiu X, Llobet-Navàs D
Autophagy 2021 May;17(5):1077-1095. Epub 2020 May 13 doi: 10.1080/15548627.2020.1752548. PMID: 32401642Free PMC Article
Transvaginal morcellation.
Clark Donat L, Clark M, Tower AM, Menderes G, Parkash V, Silasi DA, Azodi M
JSLS 2015 Apr-Jun;19(2) doi: 10.4293/JSLS.2014.00255. PMID: 26005318Free PMC Article
Consensus statement on the use of gonadotropin-releasing hormone analogs in children.
Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR; ESPE-LWPES GnRH Analogs Consensus Conference Group, Antoniazzi F, Berenbaum S, Bourguignon JP, Chrousos GP, Coste J, Deal S, de Vries L, Foster C, Heger S, Holland J, Jahnukainen K, Juul A, Kaplowitz P, Lahlou N, Lee MM, Lee P, Merke DP, Neely EK, Oostdijk W, Phillip M, Rosenfield RL, Shulman D, Styne D, Tauber M, Wit JM
Pediatrics 2009 Apr;123(4):e752-62. Epub 2009 Mar 30 doi: 10.1542/peds.2008-1783. PMID: 19332438
Cytochrome P450-mediated metabolism of estrogens and its regulation in human.
Tsuchiya Y, Nakajima M, Yokoi T
Cancer Lett 2005 Sep 28;227(2):115-24. Epub 2004 Nov 19 doi: 10.1016/j.canlet.2004.10.007. PMID: 16112414

Diagnosis

Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
The Role of Microbiota in the Immunopathogenesis of Endometrial Cancer.
Sobstyl M, Brecht P, Sobstyl A, Mertowska P, Grywalska E
Int J Mol Sci 2022 May 20;23(10) doi: 10.3390/ijms23105756. PMID: 35628566Free PMC Article
Metabolic dysfunction-associated fatty liver disease and the risk of 24 specific cancers.
Liu Z, Lin C, Suo C, Zhao R, Jin L, Zhang T, Chen X
Metabolism 2022 Feb;127:154955. Epub 2021 Dec 14 doi: 10.1016/j.metabol.2021.154955. PMID: 34915036
Radiation Dosimetry and Biodistribution of (68)Ga-FAPI-46 PET Imaging in Cancer Patients.
Meyer C, Dahlbom M, Lindner T, Vauclin S, Mona C, Slavik R, Czernin J, Haberkorn U, Calais J
J Nucl Med 2020 Aug;61(8):1171-1177. Epub 2019 Dec 13 doi: 10.2967/jnumed.119.236786. PMID: 31836685Free PMC Article
Polycystic ovarian disease.
Raj SG, Talbert LM
Obstet Gynecol Annu 1984;13:261-73. PMID: 6232474

Therapy

Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
Correlation of (68)Ga-FAPi-46 PET Biodistribution with FAP Expression by Immunohistochemistry in Patients with Solid Cancers: Interim Analysis of a Prospective Translational Exploratory Study.
Mona CE, Benz MR, Hikmat F, Grogan TR, Lueckerath K, Razmaria A, Riahi R, Slavik R, Girgis MD, Carlucci G, Kelly KA, French SW, Czernin J, Dawson DW, Calais J
J Nucl Med 2022 Jul;63(7):1021-1026. Epub 2021 Nov 5 doi: 10.2967/jnumed.121.262426. PMID: 34740953Free PMC Article
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
The microbiome and gynaecological cancer development, prevention and therapy.
Łaniewski P, Ilhan ZE, Herbst-Kralovetz MM
Nat Rev Urol 2020 Apr;17(4):232-250. Epub 2020 Feb 18 doi: 10.1038/s41585-020-0286-z. PMID: 32071434Free PMC Article
Contraception.
Mishell DR Jr
Am J Dis Child 1978 Sep;132(9):912-20. doi: 10.1001/archpedi.1978.02120340088019. PMID: 356591

Prognosis

The Role of Microbiota in the Immunopathogenesis of Endometrial Cancer.
Sobstyl M, Brecht P, Sobstyl A, Mertowska P, Grywalska E
Int J Mol Sci 2022 May 20;23(10) doi: 10.3390/ijms23105756. PMID: 35628566Free PMC Article
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
Sentinel node navigation surgery in cervical and endometrial cancer: a review.
Niikura H, Tsuji K, Tokunaga H, Shimada M, Ishikawa M, Yaegashi N
Jpn J Clin Oncol 2019 Jun 1;49(6):495-500. doi: 10.1093/jjco/hyz062. PMID: 31070770
Prevalence of malnutrition and current use of nutrition support in patients with cancer.
Hébuterne X, Lemarié E, Michallet M, de Montreuil CB, Schneider SM, Goldwasser F
JPEN J Parenter Enteral Nutr 2014 Feb;38(2):196-204. doi: 10.1177/0148607113502674. PMID: 24748626
Smoking and pregnancy.
Abel EL
J Psychoactive Drugs 1984 Oct-Dec;16(4):327-38. doi: 10.1080/02791072.1984.10472303. PMID: 6520656

Clinical prediction guides

Surgical techniques for mini-laparotomy myomectomy.
Russo ML, Gallant T, King CR
Fertil Steril 2023 Dec;120(6):1262-1263. Epub 2023 Sep 9 doi: 10.1016/j.fertnstert.2023.08.973. PMID: 37690734
Use of Straighteners and Other Hair Products and Incident Uterine Cancer.
Chang CJ, O'Brien KM, Keil AP, Gaston SA, Jackson CL, Sandler DP, White AJ
J Natl Cancer Inst 2022 Dec 8;114(12):1636-1645. doi: 10.1093/jnci/djac165. PMID: 36245087Free PMC Article
Correlation of (68)Ga-FAPi-46 PET Biodistribution with FAP Expression by Immunohistochemistry in Patients with Solid Cancers: Interim Analysis of a Prospective Translational Exploratory Study.
Mona CE, Benz MR, Hikmat F, Grogan TR, Lueckerath K, Razmaria A, Riahi R, Slavik R, Girgis MD, Carlucci G, Kelly KA, French SW, Czernin J, Dawson DW, Calais J
J Nucl Med 2022 Jul;63(7):1021-1026. Epub 2021 Nov 5 doi: 10.2967/jnumed.121.262426. PMID: 34740953Free PMC Article
Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
HIFU Tissue Ablation: Concept and Devices.
Ter Haar G
Adv Exp Med Biol 2016;880:3-20. doi: 10.1007/978-3-319-22536-4_1. PMID: 26486329

Recent systematic reviews

Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S
BMC Med 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. PMID: 34906131Free PMC Article
Association between obesity and the risk of uterine fibroids: a systematic review and meta-analysis.
Qin H, Lin Z, Vásquez E, Luan X, Guo F, Xu L
J Epidemiol Community Health 2021 Feb;75(2):197-204. Epub 2020 Oct 16 doi: 10.1136/jech-2019-213364. PMID: 33067250
The Role of Zinc in Selected Female Reproductive System Disorders.
Nasiadek M, Stragierowicz J, Klimczak M, Kilanowicz A
Nutrients 2020 Aug 16;12(8) doi: 10.3390/nu12082464. PMID: 32824334Free PMC Article
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma.
Galaal K, van der Heijden E, Godfrey K, Naik R, Kucukmetin A, Bryant A, Das N, Lopes AD
Cochrane Database Syst Rev 2013 Feb 28;2013(2):CD006812. doi: 10.1002/14651858.CD006812.pub3. PMID: 23450572Free PMC Article
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma.
Galaal K, Godfrey K, Naik R, Kucukmetin A, Bryant A
Cochrane Database Syst Rev 2011 Jan 19;(1):CD006812. doi: 10.1002/14651858.CD006812.pub2. PMID: 21249682Free PMC Article

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