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Cardiac hypertrophy

MedGen UID:
237196
•Concept ID:
C1383860
•
Pathologic Function
Synonyms: Cardiac Hypertrophies; Cardiac Hypertrophy; Heart Hypertrophies; Heart Hypertrophy; Hypertrophies, Cardiac; Hypertrophies, Heart; Hypertrophy, Cardiac; Hypertrophy, Heart

Definition

Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix. [from MeSH]

Professional guidelines

PubMed

Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure.
Verdino P, Lee SL, Cooper FN, Cottle SR, Grealish PF, Hu CC, Meyer CM, Lin J, Copeland V, Porter G, Schroeder RL, Thompson TD, Porras LL, Dey A, Zhang HY, Beebe EC, Matkovich SJ, Coskun T, Balciunas AM, Ferrante A, Siegel R, Malherbe L, Bivi N, Paavola CD, Hansen RJ, Abernathy MM, Nwosu SO, Carr MC, Heuer JG, Wang X
Br J Pharmacol 2023 Aug;180(15):1965-1980. Epub 2023 Mar 8 doi: 10.1111/bph.16055. PMID: 36780899
Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy.
Adams D, Ando Y, Beirão JM, Coelho T, Gertz MA, Gillmore JD, Hawkins PN, Lousada I, Suhr OB, Merlini G
J Neurol 2021 Jun;268(6):2109-2122. Epub 2020 Jan 6 doi: 10.1007/s00415-019-09688-0. PMID: 31907599Free PMC Article
An expert consensus document on the management of cardiovascular manifestations of Fabry disease.
Linhart A, Germain DP, Olivotto I, Akhtar MM, Anastasakis A, Hughes D, Namdar M, Pieroni M, Hagège A, Cecchi F, Gimeno JR, Limongelli G, Elliott P
Eur J Heart Fail 2020 Jul;22(7):1076-1096. Epub 2020 Aug 14 doi: 10.1002/ejhf.1960. PMID: 32640076

Recent clinical studies

Etiology

The Microenvironment of the Pathogenesis of Cardiac Hypertrophy.
Bazgir F, Nau J, Nakhaei-Rad S, Amin E, Wolf MJ, Saucerman JJ, Lorenz K, Ahmadian MR
Cells 2023 Jul 4;12(13) doi: 10.3390/cells12131780. PMID: 37443814Free PMC Article
Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy.
Zhao M, Wei H, Li C, Zhan R, Liu C, Gao J, Yi Y, Cui X, Shan W, Ji L, Pan B, Cheng S, Song M, Sun H, Jiang H, Cai J, Garcia-Barrio MT, Chen YE, Meng X, Dong E, Wang DW, Zheng L
Nat Commun 2022 Apr 1;13(1):1757. doi: 10.1038/s41467-022-29060-7. PMID: 35365608Free PMC Article
Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.
Wang F, Liang Q, Ma Y, Sun M, Li T, Lin L, Sun Z, Duan J
Free Radic Biol Med 2022 Mar;182:171-181. Epub 2022 Feb 24 doi: 10.1016/j.freeradbiomed.2022.02.027. PMID: 35219847
Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy.
Luo Y, Jiang N, May HI, Luo X, Ferdous A, Schiattarella GG, Chen G, Li Q, Li C, Rothermel BA, Jiang D, Lavandero S, Gillette TG, Hill JA
Circulation 2021 Jul 6;144(1):34-51. Epub 2021 Apr 6 doi: 10.1161/CIRCULATIONAHA.120.052384. PMID: 33821668Free PMC Article
Physiological and pathological cardiac hypertrophy.
Shimizu I, Minamino T
J Mol Cell Cardiol 2016 Aug;97:245-62. Epub 2016 Jun 2 doi: 10.1016/j.yjmcc.2016.06.001. PMID: 27262674

Diagnosis

Molecular biomarkers in cardiac hypertrophy.
Zhu L, Li C, Liu Q, Xu W, Zhou X
J Cell Mol Med 2019 Mar;23(3):1671-1677. Epub 2019 Jan 16 doi: 10.1111/jcmm.14129. PMID: 30648807Free PMC Article
Circular RNA in cardiovascular disease.
Altesha MA, Ni T, Khan A, Liu K, Zheng X
J Cell Physiol 2019 May;234(5):5588-5600. Epub 2018 Oct 20 doi: 10.1002/jcp.27384. PMID: 30341894
Hypertrophic obstructive cardiomyopathy.
Veselka J, Anavekar NS, Charron P
Lancet 2017 Mar 25;389(10075):1253-1267. Epub 2016 Nov 30 doi: 10.1016/S0140-6736(16)31321-6. PMID: 27912983
Physiological and pathological cardiac hypertrophy.
Shimizu I, Minamino T
J Mol Cell Cardiol 2016 Aug;97:245-62. Epub 2016 Jun 2 doi: 10.1016/j.yjmcc.2016.06.001. PMID: 27262674
Cardiorenal syndrome.
Ronco C, Haapio M, House AA, Anavekar N, Bellomo R
J Am Coll Cardiol 2008 Nov 4;52(19):1527-39. doi: 10.1016/j.jacc.2008.07.051. PMID: 19007588

Therapy

Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders.
Samidurai A, Xi L, Das A, Kukreja RC
Annu Rev Pharmacol Toxicol 2023 Jan 20;63:585-615. Epub 2022 Oct 7 doi: 10.1146/annurev-pharmtox-040122-034745. PMID: 36206989
Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure.
Kamel R, Leroy J, Vandecasteele G, Fischmeister R
Nat Rev Cardiol 2023 Feb;20(2):90-108. Epub 2022 Sep 1 doi: 10.1038/s41569-022-00756-z. PMID: 36050457
Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy.
Ren Z, Yu P, Li D, Li Z, Liao Y, Wang Y, Zhou B, Wang L
Circulation 2020 May 26;141(21):1704-1719. Epub 2020 Feb 26 doi: 10.1161/CIRCULATIONAHA.119.043053. PMID: 32098504
Pleiotropic Effects of Statins on the Cardiovascular System.
Oesterle A, Laufs U, Liao JK
Circ Res 2017 Jan 6;120(1):229-243. doi: 10.1161/CIRCRESAHA.116.308537. PMID: 28057795Free PMC Article
The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview.
Wu Q, Liu L, Miron A, Klímová B, Wan D, Kuča K
Arch Toxicol 2016 Aug;90(8):1817-40. Epub 2016 Jun 3 doi: 10.1007/s00204-016-1744-5. PMID: 27259333

Prognosis

Precision Hypertension.
Dzau VJ, Hodgkinson CP
Hypertension 2024 Apr;81(4):702-708. Epub 2023 Dec 19 doi: 10.1161/HYPERTENSIONAHA.123.21710. PMID: 38112080
Role of Irisin in Myocardial Infarction, Heart Failure, and Cardiac Hypertrophy.
Ho MY, Wang CY
Cells 2021 Aug 16;10(8) doi: 10.3390/cells10082103. PMID: 34440871Free PMC Article
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.
Marian AJ, Braunwald E
Circ Res 2017 Sep 15;121(7):749-770. doi: 10.1161/CIRCRESAHA.117.311059. PMID: 28912181Free PMC Article
Cardiorenal syndrome.
Ronco C, Haapio M, House AA, Anavekar N, Bellomo R
J Am Coll Cardiol 2008 Nov 4;52(19):1527-39. doi: 10.1016/j.jacc.2008.07.051. PMID: 19007588
Pompe's disease.
van der Ploeg AT, Reuser AJ
Lancet 2008 Oct 11;372(9646):1342-53. doi: 10.1016/S0140-6736(08)61555-X. PMID: 18929906

Clinical prediction guides

Precision Hypertension.
Dzau VJ, Hodgkinson CP
Hypertension 2024 Apr;81(4):702-708. Epub 2023 Dec 19 doi: 10.1161/HYPERTENSIONAHA.123.21710. PMID: 38112080
Angiotensin II-Induced Signal Transduction Mechanisms for Cardiac Hypertrophy.
Bhullar SK, Dhalla NS
Cells 2022 Oct 22;11(21) doi: 10.3390/cells11213336. PMID: 36359731Free PMC Article
Targeting miR-30d reverses pathological cardiac hypertrophy.
Li J, Sha Z, Zhu X, Xu W, Yuan W, Yang T, Jin B, Yan Y, Chen R, Wang S, Yao J, Xu J, Wang Z, Li G, Das S, Yang L, Xiao J
EBioMedicine 2022 Jul;81:104108. Epub 2022 Jun 22 doi: 10.1016/j.ebiom.2022.104108. PMID: 35752105Free PMC Article
Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy.
Ren Z, Yu P, Li D, Li Z, Liao Y, Wang Y, Zhou B, Wang L
Circulation 2020 May 26;141(21):1704-1719. Epub 2020 Feb 26 doi: 10.1161/CIRCULATIONAHA.119.043053. PMID: 32098504
Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.
Marian AJ, Braunwald E
Circ Res 2017 Sep 15;121(7):749-770. doi: 10.1161/CIRCRESAHA.117.311059. PMID: 28912181Free PMC Article

Recent systematic reviews

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases.
Liu X, Xu X, Zhang T, Xu L, Tao H, Liu Y, Zhang Y, Meng X
Phytother Res 2023 Nov;37(11):4976-4998. Epub 2023 Aug 2 doi: 10.1002/ptr.7965. PMID: 37533230
Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta-analysis.
Liu Z, Thergarajan P, Antonic-Baker A, Chen Z, Sparks PB, Lannin NA, Kwan P, Jones NC, Casillas-Espinosa PM, Perucca P, O'Brien TJ, Sivathamboo S
Epilepsia Open 2023 Mar;8(1):46-59. Epub 2023 Jan 31 doi: 10.1002/epi4.12692. PMID: 36648338Free PMC Article
The molecular mechanisms of ferroptosis and its role in cardiovascular disease.
Zhang Y, Xin L, Xiang M, Shang C, Wang Y, Wang Y, Cui X, Lu Y
Biomed Pharmacother 2022 Jan;145:112423. Epub 2021 Nov 17 doi: 10.1016/j.biopha.2021.112423. PMID: 34800783
Effect of maternal diabetes on fetal heart function on echocardiography: systematic review and meta-analysis.
Depla AL, De Wit L, Steenhuis TJ, Slieker MG, Voormolen DN, Scheffer PG, De Heus R, Van Rijn BB, Bekker MN
Ultrasound Obstet Gynecol 2021 Apr;57(4):539-550. doi: 10.1002/uog.22163. PMID: 32730637Free PMC Article
Left-ventricular hypertrophy and obesity: a systematic review and meta-analysis of echocardiographic studies.
Cuspidi C, Rescaldani M, Sala C, Grassi G
J Hypertens 2014 Jan;32(1):16-25. doi: 10.1097/HJH.0b013e328364fb58. PMID: 24309485

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