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Severe acute respiratory syndrome(SARS)

MedGen UID:
262817
Concept ID:
C1175175
Disease or Syndrome
Synonym: SARS
SNOMED CT: Severe acute respiratory syndrome (398447004); SARS (398447004); SARS-CoV infection (398447004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005091
Orphanet: ORPHA140896

Definition

A rare pulmonary disease induced by SARS-CoV coronavirus infection, with a reported incubation period varying from 2 to 7 days. Patients present flu-like symptoms, including fever, malaise, myalgia, headache, diarrhoea, and rigors. Dry, nonproductive, cough and dyspnea are frequently reported. Severe cases evolve rapidly, progressing to respiratory distress and failure, requiring intensive care. Mortality rate is 10%. The disease appeared in 2002 in southern China, subsequently spreading in 2003 to 26 countries. Reported human-to-human transmission occurred in Toronto (Canada), Hong Kong Special Administrative Region of China, Chinese Taipei, Singapore, and Hanoi (Viet Nam). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSevere acute respiratory syndrome
Follow this link to review classifications for Severe acute respiratory syndrome in Orphanet.

Professional guidelines

PubMed

Yuan Y, Jiao B, Qu L, Yang D, Liu R
Front Immunol 2023;14:1125246. Epub 2023 Jan 26 doi: 10.3389/fimmu.2023.1125246. PMID: 36776881Free PMC Article
Ochani R, Asad A, Yasmin F, Shaikh S, Khalid H, Batra S, Sohail MR, Mahmood SF, Ochani R, Hussham Arshad M, Kumar A, Surani S
Infez Med 2021 Mar 1;29(1):20-36. PMID: 33664170
Umakanthan S, Sahu P, Ranade AV, Bukelo MM, Rao JS, Abrahao-Machado LF, Dahal S, Kumar H, Kv D
Postgrad Med J 2020 Dec;96(1142):753-758. Epub 2020 Jun 20 doi: 10.1136/postgradmedj-2020-138234. PMID: 32563999Free PMC Article

Recent clinical studies

Etiology

Pusterla N
Vet Clin North Am Equine Pract 2023 Apr;39(1):55-71. Epub 2022 Nov 21 doi: 10.1016/j.cveq.2022.11.008. PMID: 36737293
Barman A, Sinha MK, Sahoo J, Jena D, Patel V
Heart Lung 2022 May-Jun;53:11-24. Epub 2022 Jan 14 doi: 10.1016/j.hrtlng.2022.01.005. PMID: 35108624Free PMC Article
Martin-Loeches I, Soares M, Torres A
Intensive Care Med 2016 May;42(5):928-930. Epub 2016 Feb 3 doi: 10.1007/s00134-016-4243-5. PMID: 26846514Free PMC Article
Weiss SR, Navas-Martin S
Microbiol Mol Biol Rev 2005 Dec;69(4):635-64. doi: 10.1128/MMBR.69.4.635-664.2005. PMID: 16339739Free PMC Article
Chan-Yeung M, Xu RH
Respirology 2003 Nov;8 Suppl(Suppl 1):S9-14. doi: 10.1046/j.1440-1843.2003.00518.x. PMID: 15018127Free PMC Article

Diagnosis

Choi YK
Exp Mol Med 2021 May;53(5):711-712. Epub 2021 May 6 doi: 10.1038/s12276-021-00608-9. PMID: 33953321Free PMC Article
Dis Mon 2017 Sep;63(9):256-262. Epub 2017 Sep 12 doi: 10.1016/j.disamonth.2017.03.019. PMID: 29737283Free PMC Article
Cheng VC, Lau SK, Woo PC, Yuen KY
Clin Microbiol Rev 2007 Oct;20(4):660-94. doi: 10.1128/CMR.00023-07. PMID: 17934078Free PMC Article
Chan-Yeung M, Xu RH
Respirology 2003 Nov;8 Suppl(Suppl 1):S9-14. doi: 10.1046/j.1440-1843.2003.00518.x. PMID: 15018127Free PMC Article
Drosten C, Günther S, Preiser W, van der Werf S, Brodt HR, Becker S, Rabenau H, Panning M, Kolesnikova L, Fouchier RA, Berger A, Burguière AM, Cinatl J, Eickmann M, Escriou N, Grywna K, Kramme S, Manuguerra JC, Müller S, Rickerts V, Stürmer M, Vieth S, Klenk HD, Osterhaus AD, Schmitz H, Doerr HW
N Engl J Med 2003 May 15;348(20):1967-76. Epub 2003 Apr 10 doi: 10.1056/NEJMoa030747. PMID: 12690091

Therapy

Jefferson T, Dooley L, Ferroni E, Al-Ansary LA, van Driel ML, Bawazeer GA, Jones MA, Hoffmann TC, Clark J, Beller EM, Glasziou PP, Conly JM
Cochrane Database Syst Rev 2023 Jan 30;1(1):CD006207. doi: 10.1002/14651858.CD006207.pub6. PMID: 36715243Free PMC Article
Grundeis F, Ansems K, Dahms K, Thieme V, Metzendorf MI, Skoetz N, Benstoem C, Mikolajewska A, Griesel M, Fichtner F, Stegemann M
Cochrane Database Syst Rev 2023 Jan 25;1(1):CD014962. doi: 10.1002/14651858.CD014962.pub2. PMID: 36695483Free PMC Article
Minelli C, Luvizutto GJ, Cacho RO, Neves LO, Magalhães SCSA, Pedatella MTA, Mendonça LIZ, Ortiz KZ, Lange MC, Ribeiro PW, Souza LAPS, Milani C, Cruz DMCD, Costa RDMD, Conforto AB, Carvalho FMM, Ciarlini BS, Frota NAF, Almeida KJ, Schochat E, Oliveira TP, Miranda C, Piemonte MEP, Lopes LCG, Lopes CG, Tosin MHS, Oliveira BC, Oliveira BGRB, Castro SS, Andrade JBC, Silva GS, Pontes-Neto OM, Carvalho JJF, Martins SCO, Bazan R
Arq Neuropsiquiatr 2022 Jul;80(7):741-758. Epub 2022 Sep 29 doi: 10.1055/s-0042-1757692. PMID: 36254447Free PMC Article
Tregoning JS, Flight KE, Higham SL, Wang Z, Pierce BF
Nat Rev Immunol 2021 Oct;21(10):626-636. Epub 2021 Aug 9 doi: 10.1038/s41577-021-00592-1. PMID: 34373623Free PMC Article
Hu B, Huang S, Yin L
J Med Virol 2021 Jan;93(1):250-256. Epub 2020 Sep 30 doi: 10.1002/jmv.26232. PMID: 32592501Free PMC Article

Prognosis

Weaver AK, Head JR, Gould CF, Carlton EJ, Remais JV
Annu Rev Public Health 2022 Apr 5;43:271-291. Epub 2022 Jan 4 doi: 10.1146/annurev-publhealth-052120-101420. PMID: 34982587Free PMC Article
Takemoto MLS, Menezes MO, Andreucci CB, Knobel R, Sousa LAR, Katz L, Fonseca EB, Magalhães CG, Oliveira WK, Rezende-Filho J, Melo ASO, Amorim MMR
J Matern Fetal Neonatal Med 2022 Jun;35(12):2355-2361. Epub 2020 Jul 16 doi: 10.1080/14767058.2020.1786056. PMID: 32674646
Ladani AP, Loganathan M, Kolikonda MK, Lippmann S
South Med J 2021 Dec;114(12):751-759. doi: 10.14423/SMJ.0000000000001337. PMID: 34853850Free PMC Article
Thomas SJ, Moreira ED Jr, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Polack FP, Zerbini C, Bailey R, Swanson KA, Xu X, Roychoudhury S, Koury K, Bouguermouh S, Kalina WV, Cooper D, Frenck RW Jr, Hammitt LL, Türeci Ö, Nell H, Schaefer A, Ünal S, Yang Q, Liberator P, Tresnan DB, Mather S, Dormitzer PR, Şahin U, Gruber WC, Jansen KU; C4591001 Clinical Trial Group
N Engl J Med 2021 Nov 4;385(19):1761-1773. Epub 2021 Sep 15 doi: 10.1056/NEJMoa2110345. PMID: 34525277Free PMC Article
Martin-Loeches I, Soares M, Torres A
Intensive Care Med 2016 May;42(5):928-930. Epub 2016 Feb 3 doi: 10.1007/s00134-016-4243-5. PMID: 26846514Free PMC Article

Clinical prediction guides

Long B, Carius BM, Chavez S, Liang SY, Brady WJ, Koyfman A, Gottlieb M
Am J Emerg Med 2022 Apr;54:46-57. Epub 2022 Jan 21 doi: 10.1016/j.ajem.2022.01.028. PMID: 35121478Free PMC Article
Ahirwar R, Gandhi S, Komal K, Dhaniya G, Tripathi PP, Shingatgeri VM, Kumar K, Sharma JG, Kumar S
Biosci Rep 2021 Aug 27;41(8) doi: 10.1042/BSR20211238. PMID: 34291285Free PMC Article
Majumder J, Minko T
AAPS J 2021 Jan 5;23(1):14. doi: 10.1208/s12248-020-00532-2. PMID: 33400058Free PMC Article
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L
Lancet 2020 Feb 15;395(10223):507-513. Epub 2020 Jan 30 doi: 10.1016/S0140-6736(20)30211-7. PMID: 32007143Free PMC Article
Ooi CG, Khong PL, Ho JC, Lam B, Wong WM, Yiu WC, Wong PC, Wong CF, Lai KN, Tsang KW
Radiology 2003 Nov;229(2):500-6. doi: 10.1148/radiol.2292030737. PMID: 14595150

Recent systematic reviews

Chee YJ, Fan BE, Young BE, Dalan R, Lye DC
J Med Virol 2023 Jan;95(1):e28289. Epub 2022 Nov 18 doi: 10.1002/jmv.28289. PMID: 36349400Free PMC Article
Wrona M, Skrypnik D
Int J Environ Res Public Health 2022 Oct 14;19(20) doi: 10.3390/ijerph192013280. PMID: 36293857Free PMC Article
Carbone L, Trinchillo MG, Di Girolamo R, Raffone A, Saccone G, Iorio GG, Gabrielli O, Maruotti GM
Int J Gynaecol Obstet 2022 Dec;159(3):651-661. Epub 2022 Jul 29 doi: 10.1002/ijgo.14336. PMID: 35810414Free PMC Article
Tutal E, Ozaras R, Leblebicioglu H
Travel Med Infect Dis 2022 May-Jun;47:102314. Epub 2022 Mar 18 doi: 10.1016/j.tmaid.2022.102314. PMID: 35307540Free PMC Article
Pollock A, Campbell P, Cheyne J, Cowie J, Davis B, McCallum J, McGill K, Elders A, Hagen S, McClurg D, Torrens C, Maxwell M
Cochrane Database Syst Rev 2020 Nov 5;11(11):CD013779. doi: 10.1002/14651858.CD013779. PMID: 33150970Free PMC Article

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