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Twinning, monozygotic
The division of a ZYGOTE into two parts that are each capable of further development into two distinct individuals, both that have the same genetic makeup. [from MeSH]
Neutrophil actin dysfunction
Neutrophil actin dysfunction (NAD) is an immunologic disorder characterized by early onset of recurrent infections, including oral, skin, and respiratory. Organisms are mainly bacterial and fungal. Patients tend to develop fever and hepatosplenomegaly with continued infection; bone marrow transplant is an effective treatment. The disorder results from impaired neutrophil mobility and chemotaxis associated with abnormal actin dynamics. Although a causative mutation has not been identified, studies have shown an association between the disorder and increased levels of a 47-kD F-actin-binding protein known as LSP1 (153432) and decreased levels of an unknown 89-kD protein (summary by Coates et al., 1991 and Howard et al., 1998). [from OMIM]
Insulin resistance
Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels. [from HPO]
Panniculitis
Inflammation of subcutaneous adipose tissue. [from HPO]
Hyperinsulinemia
An increased concentration of insulin in the blood. [from HPO]
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