MedGen

Infection with protozoa of the genus trypanosoma. [from MONDO]

An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, rectal adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma. [from NCI]

A rare vector-borne parasitic disease caused by a protozoa of the <i>Trypanosoma</i> genus transmitted by the bite of a tsetse fly (genus <i>Glossina</i>), that is found under its chronic form (average duration of 3 years) in western and central Africa (in case of the <i>T. brucei gambiense</i> sub-species), and under its acute form (lasting from few weeks to 6 months) in eastern and southern Africa (in case of the <i>T. brucei rhodesiense</i> sub-species). HAT comprises an initial hemo-lymphatic stage characterized by fever, weakness, musculoskeletal pain, anemia, and lymphadenopathy, along with dermatologic, cardiac and endocrine complications or hepatosplenomegaly, followed by a meningo-encephalitic stage characterized by neurologic involvement (sleep disturbances, psychiatric disorders, seizures) that progresses, in the absence of treatment, towards a fatal meningoencephalitis. [from ORDO]