Perilipins

A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.

Year introduced: 2017

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D12.776.157.464.500

MeSH Unique ID: D000070137

Entry Terms:

• PAT Proteins
• Proteins, PAT
• Perilipin Proteins
• Proteins, Perilipin
• PLIN Proteins
• Proteins, PLIN
• Perilipin-Adipophilin-TIP47 Proteins
• Perilipin Adipophilin TIP47 Proteins
• Proteins, Perilipin-Adipophilin-TIP47

Previous Indexing:

• Carrier Proteins (1991-2016)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Carrier Proteins
Lipid Droplet Associated Proteins
Perilipins
Perilipin-1
Perilipin-2
Perilipin-3
Perilipin-4
Perilipin-5