Nogo Proteins
Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
Year introduced: 2017 (2000)
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Subheadings:
Tree Number(s): D12.776.543.620.738, D12.776.631.580.738
MeSH Unique ID: D000070798
Entry Terms:
- Nogo Protein
- Reticulon-4 Protein
- Reticulon 4 Protein
- Nogo-66 Protein
- Nogo 66 Protein
- Neurite Growth Inhibitor 35-350
- Neurite Growth Inhibitor 35 350
- NI-35-250
- NI 35 250
- Nogo-A Protein
- Nogo A Protein
- NI-220 Protein
- NI 220 Protein
- NI-250 Protein
- NI 250 Protein
- Nogo-B Protein
- Nogo B Protein
- Reticulon 4-B Protein
- Reticulon 4 B Protein
- Nogo-C Protein
- Nogo C Protein
- NI-35 Protein
- NI 35 Protein