Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).
Year introduced: 2017
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Subheadings:
Tree Number(s): D08.811.913.696.620.682.700.534, D12.776.476.563.534, D12.776.705.750
MeSH Unique ID: D000071158
Registry Number: EC 2.7.11.1
Entry Terms:
- Leucine Rich Repeat Serine Threonine Protein Kinase 2
- LRRK2 Protein
- PARK8 Protein
- Dardarin Protein
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