Werner Syndrome Helicase
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
Year introduced: 2017
PubMed search builder options
Subheadings:
Tree Number(s): D08.811.277.040.025.159.249.500, D08.811.277.352.335.375.875, D08.811.277.352.365.290.500, D08.811.399.340.249.500, D12.776.157.687.750, D12.776.660.720.750
MeSH Unique ID: D000071657
Registry Number: EC 3.6.4.12
Entry Terms:
- Helicase, Werner Syndrome
- Werner Syndrome RecQ-Like Helicase
- Werner Syndrome RecQ Like Helicase
- RECQ3 Protein
- RECQL2 Protein
- Werner Syndrome ATP-Dependent Helicase
- Werner Syndrome ATP Dependent Helicase
Previous Indexing: