High-Temperature Requirement A Serine Peptidase 1

A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).

Year introduced: 2018

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Tree Number(s): D08.811.277.656.300.760.420, D08.811.277.656.959.350.420

MeSH Unique ID: D000074289

Registry Number: EC 3.4.21.-

Entry Terms:

• High Temperature Requirement A Serine Peptidase 1
• Serine Protease HTRA1
• HTRA1, Serine Protease
• Protease HTRA1, Serine

Previous Indexing:

• Serine Endopeptidases (2003-2017)

See Also:

• PDZ Domains
• Kazal Motifs

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Peptide Hydrolases
Endopeptidases
Serine Endopeptidases
High-Temperature Requirement A Serine Peptidase 1

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Peptide Hydrolases
Serine Proteases
Serine Endopeptidases
High-Temperature Requirement A Serine Peptidase 1