Osteocalcin

Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.

Year introduced: 1990

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Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D12.776.157.125.700

MeSH Unique ID: D015675

Registry Number: 104982-03-8

Entry Terms:

• 4-Carboxyglutamic Protein, Bone
• 4 Carboxyglutamic Protein, Bone
• Bone 4-Carboxyglutamic Protein
• Protein, Bone 4-Carboxyglutamic
• Bone gamma-Carboxyglutamic Acid Protein
• Bone gamma Carboxyglutamic Acid Protein
• Bone Gla Protein
• Protein, Bone Gla
• Calcium-Binding Protein, Vitamin K-Dependent
• Calcium Binding Protein, Vitamin K Dependent
• Gla Protein, Bone
• Vitamin K-Dependent Bone Protein
• Vitamin K Dependent Bone Protein

Previous Indexing:

• 1-Carboxyglutamic Acid (1978-1981)
• Binding Proteins (1978-1980)
• Calcium (1978-1980)
• Calcium-Binding Proteins (1980-1989)
• Proteins (1980-1981)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Carrier Proteins
Calcium-Binding Proteins
Osteocalcin