RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Year introduced: 2003
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Subheadings:
Tree Number(s): D13.150.650.700, D13.444.735.150.700, D13.444.735.790.552.875
MeSH Unique ID: D034741
Entry Terms:
- Interfering RNA, Small
- siRNA
- Small Interfering RNA
- Short Interfering RNA
- Interfering RNA, Short
- RNA, Short Interfering
- Scan RNA
- RNA, Scan
- scnRNA
- Small Scan RNA
- RNA, Small Scan
- Scan RNA, Small
- Repeat-Associated siRNA
- Repeat Associated siRNA
- siRNA, Repeat-Associated
- siRNA, Repeat Associated
- Trans-Acting siRNA
- Trans Acting siRNA
- siRNA, Trans-Acting
- siRNA, Trans Acting
- tasiRNA
- Short Hairpin RNA
- Hairpin RNA, Short
- RNA, Short Hairpin
- shRNA
- Small Hairpin RNA
- Hairpin RNA, Small
- RNA, Small Hairpin
See Also: