Inhibitor of Apoptosis Proteins
A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.
Year introduced: 2006(1997)
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Subheadings:
Tree Number(s): D08.811.464.938.750.210, D12.644.360.075.437, D12.776.476.075.437
MeSH Unique ID: D051034
Entry Terms:
- Apoptosis Proteins Inhibitor
- Inhibitor-Of-Apoptosis Protein
- Inhibitor Of Apoptosis Protein
- IAP Protein (Apoptosis)
- Baculoviral Inhibitor Of Apoptosis Repeat Proteins
- IAP Repeat Containing Proteins
- Baculoviral IAP Repeat-Containing 2 Protein
- Baculoviral IAP Repeat Containing 2 Protein
- BIRC2 Protein
- Cellular Inhibitor of Apoptosis 1 Protein
- Baculoviral IAP Repeat Containing Protein 2
- c-IAP1 Protein
- cIAP1 Protein
- Inhibitor of Apoptosis 2 Protein
- IAP2 Protein
Pharmacologic Action: