Presenilin-1

Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN1 mutations cause early-onset ALZHEIMER DISEASE type 3 that may occur as early as 30 years of age in humans.

Year introduced: 2007

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Tree Number(s): D12.776.543.696.500

MeSH Unique ID: D053764

Entry Terms:

• Presenilin 1
• S182 Protein

Previous Indexing:

• Alzheimer Disease (1995-2006)
• Membrane Proteins (1995-2006)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Membrane Proteins
Presenilins
Presenilin-1