Sterol 14-Demethylase
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.
Year introduced: 2011
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Subheadings:
Tree Number(s): D08.244.453.878.500, D08.244.453.915.880, D08.811.682.690.708.170.499.500, D08.811.682.690.708.170.915.880, D12.776.422.220.453.878.500, D12.776.422.220.453.915.880
MeSH Unique ID: D058886
Registry Number: EC 1.14.14.154
Entry Terms:
- 14-Demethylase, Sterol
- Sterol 14 Demethylase
- Sterol 14-Demethylases
- 14-Demethylases, Sterol
- Sterol 14 Demethylases
- Sterol 14-alpha-Demethylase
- 14-alpha-Demethylase, Sterol
- Sterol 14 alpha Demethylase
- Lanosterol 14 alpha-Demethylase
- 14 alpha-Demethylase, Lanosterol
- Lanosterol 14 alpha Demethylase
- Eburicol 14 alpha-Demethylase
- 14 alpha-Demethylase, Eburicol
- Eburicol 14 alpha Demethylase
- Eburicol 14alpha-Demethylase
- 14alpha-Demethylase, Eburicol
- Eburicol 14alpha Demethylase
- Obtusifoliol 14alpha-Demethylase
- 14alpha-Demethylase, Obtusifoliol
- Obtusifoliol 14alpha Demethylase
- Cytochrome P-450 CYP51
- CYP51, Cytochrome P-450
- Cytochrome P 450 CYP51
- P-450 CYP51, Cytochrome
- CYP51 Cytochrome P-450
- CYP51 Cytochrome P 450
- Cytochrome P-450, CYP51
- P-450, CYP51 Cytochrome