MeSH

A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.

Year introduced: 1998

Vesicular amine transporter proteins that transport the neurotransmitter ACETYLCHOLINE into small SECRETORY VESICLES. Proteins of this family contain 12 transmembrane domains and exchange vesicular PROTONS for cytoplasmic acetylcholine.

Year introduced: 2006(1992)

Compounds that block release of the neurotransmitter ACETYLCHOLINE.

Year introduced: 2015

A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric α7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.

Year introduced: 2014

One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.

Year introduced: 1984(1977)

One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3....) that are characterized by their cellular actions, pharmacology, and molecular biology.

Year introduced: 1984(1977)

Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists.

Year introduced: 1995

Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.

Year introduced: 1995

Cell surface proteins that bind acetylcholine with high affinity and trigger intracellular changes influencing the behavior of cells. Cholinergic receptors are divided into two major classes, muscarinic and nicotinic, based originally on their affinity for nicotine and muscarine. Each group is further subdivided based on pharmacology, location, mode of action, and/or molecular biology.

Year introduced: 1974(1971)

Drugs that bind to and activate cholinergic receptors.

Year introduced: 1995

Date introduced: February 2, 2001

Date introduced: August 18, 1998

synthetic peptide (125-148) of the alpha-subunit of human nicotinic acetylcholine receptor

Date introduced: December 5, 1990

amino acid sequence given in first source

Date introduced: August 20, 1990

An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.

nictonic receptors that contain alpha6 and beta2 subunits

Date introduced: July 15, 2011

RefSeq NM_080359

Date introduced: August 31, 2011

Myasthenic syndrome, congenital (postsynaptic) associated with acetylcholine receptor deficiency

Date introduced: August 25, 2010

synthetic peptide corresponding to first 20 amino acids of N-terminal region of alpha subunit of Torpedo nicotinic acetylcholine receptor; amino acid sequence given in first source

Date introduced: July 18, 1984

Date introduced: October 24, 1980