"Amiloride" - MeSH

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Select item 680005841.

A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

Year introduced: 1986(1972)

Select item 670102472.

amiloride, hydrochlorothiazide drug combination [Supplementary Concept]

amiloride hydrochloride and hydrochlorothiazide drug combination.

Date introduced: January 1, 1975

Select item 680535033.

Epithelial Sodium Channels

Sodium channels found on salt-reabsorbing EPITHELIAL CELLS that line the distal NEPHRON; the distal COLON; SALIVARY DUCTS; SWEAT GLANDS; and the LUNG. They are AMILORIDE-sensitive and play a critical role in the control of sodium balance, BLOOD VOLUME, and BLOOD PRESSURE.

Year introduced: 2013(1995)

Select item 674859584.

Dao1 protein, mouse [Supplementary Concept]

RefSeq NM_010018

Date introduced: August 6, 2004

Select item 671122315.

ASIC3 protein, human [Supplementary Concept]

RefSeq NM_004769

Date introduced: June 1, 1998

Select item 670970956.

FaNaCh protein, Helix aspersa [Supplementary Concept]

from two snail species; a peptide-gated ionotropic receptor 16% identical to ENaCh sodium channel and 13% identical to degenerins such as Mec-4; GenBank Z48045

Date introduced: January 15, 1996

Select item 670846337.

5-(N-methyl-N-propyl)amiloride [Supplementary Concept]

structure given in first source

Date introduced: January 5, 1994

Select item 670669168.

amiloride, bumetanide drug combination [Supplementary Concept]

drug combination consisting of the above cpds; used in treatment of patients with congestive cardiac failure

Date introduced: February 23, 1991

Select item 670610079.

5-(N-ethyl-(2'-methoxy-5'-nitrobenzyl))amiloride [Supplementary Concept]

bradykinin antagonist

Date introduced: October 16, 1989

Select item 6705736010.

5-(N,N-hexamethylene)amiloride [Supplementary Concept]

inhibitor of Na+-H+ exchange; has anti-HIV-1 activity

Date introduced: November 14, 1988

Select item 6704765711.

amiloride caproate [Supplementary Concept]

used to raise anti-amiloride antibodies; structure given in first source

Date introduced: February 18, 1986

Select item 6703961412.

ethylisopropylamiloride [Supplementary Concept]

structure in first source

Date introduced: December 7, 1983

Select item 6703946513.

5-dimethylamiloride [Supplementary Concept]

has anti-HIV-1 activity

Date introduced: November 16, 1983

Select item 6806256514.

Acid Sensing Ion Channels

A family of proton-gated sodium channels that are primarily expressed in neuronal tissue. They are AMILORIDE-sensitive and are implicated in the signaling of a variety of neurological stimuli, most notably that of pain in response to acidic conditions.

Year introduced: 2013

Select item 6801983515.

FMRFamide

A molluscan neuroactive peptide which induces a fast excitatory depolarizing response due to direct activation of amiloride-sensitive SODIUM CHANNELS. (From Nature 1995; 378(6558): 730-3)

Year introduced: 1998

Select item 6758441216.

5-benzylglycinyl amiloride [Supplementary Concept]

structure in first source

Date introduced: November 16, 2013

Select item 6756842517.

Asic2 protein, rat [Supplementary Concept]

RefSeq NM_001034014

Date introduced: August 20, 2012

Select item 6756842418.

ASIC2 protein, human [Supplementary Concept]

RefSeq NM_183377