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Calcitriol
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Year introduced: 1982
Receptors, Calcitriol
Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.
Year introduced: 1994
Vitamin D3 24-Hydroxylase
A cytochrome P-450 enzyme that has specificity for CHOLECALCIFEROL (Vitamin D3). It hydroxylates the molecule at carbon position 24.
Year introduced: 2015 (1978)
1,25-dihydroxyvitamin D3-23,26-lactol [Supplementary Concept]
in calcitriol proposed metabolic pathway; structure given in first source; RN given refers to ((23R,25S)-isomer); RN for cpd without isomeric designation not available 1/89
Date introduced: June 23, 1987
26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3 [Supplementary Concept]
long lasting analog of calcitriol; RN given refers to (1alpha,3beta,5Z,7E)-isomer
Date introduced: March 30, 1984
Solanum glaucophyllum
A plant species of the genus SOLANUM, family SOLANACEAE that causes CALCINOSIS in grazing livestock due to high levels of 1a,25-dihydroxy vitamin D3 (CALCITRIOL).
Year introduced: 2003
Vitamin D Response Element
A DNA sequence that is found in the promoter region of vitamin D regulated genes. Vitamin D receptor (RECEPTOR, CALCITRIOL) binds to and regulates the activity of genes containing this element.
Year introduced: 2002
Phosphorus, Dietary
Phosphorus used in foods or obtained from food. This element is a major intracellular component which plays an important role in many biochemical pathways relating to normal physiological functions. High concentrations of dietary phosphorus can cause nephrocalcinosis which is associated with impaired kidney function. Low concentrations of dietary phosphorus cause an increase in calcitriol in the blood and osteoporosis.
Year introduced: 1991
24,25-Dihydroxyvitamin D 3
A physiologically active metabolite of VITAMIN D. The compound is involved in the regulation of calcium metabolism, alkaline phosphatase activity, and enhancing the calcemic effect of CALCITRIOL.
Year introduced: 1990
Vitamin D
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Hydroxycholecalciferols
Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.
Year introduced: 1975
Cholecalciferol
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
Year introduced: 1994, 1967-1974
eldecalcitol [Supplementary Concept]
structure in first source
Date introduced: March 5, 2010
BXL628 [Supplementary Concept]
a calcitriol analog for Inhibition of prostate cell growth; in phase II clinical trial in patients with benign prostate hyperplasia (4/2004)
Date introduced: June 17, 2004
25-O-ethyl-calcitriol [Supplementary Concept]
structure given in first source
Date introduced: December 21, 1995
22-dehydro-1,25-dihydroxy-24-dihomovitamin D3 [Supplementary Concept]
an interleukin-6 and 8 antagonist
Date introduced: July 5, 1994
22-dehydro-1,25-dihydroxy-24-homovitamin D3 [Supplementary Concept]
24,24-difluoro-1,25-dihydroxy-26,27-dimethylvitamin D3 [Supplementary Concept]
RN & structure given in first source
Date introduced: March 8, 1990
26-homo-1,25-dihydroxyvitamin D3 [Supplementary Concept]
Date introduced: June 5, 1987
24-homo-1,25-dihydroxyvitamin D3 [Supplementary Concept]