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Calpain
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.
Year introduced: 1986
calpain 10 [Supplementary Concept]
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodelling and signal tranduction; genetic variation in CAPN10 is associated with type 2 diabetes mellitus
Date introduced: November 4, 2000
calpain Lp82 [Supplementary Concept]
a lens-specific, calcium-activated isozyme from the calpain super family of cysteine proteases; Lp85 is an isoenzyme of Lp82; amino acid sequence in first source; GenBank AF091998
Date introduced: May 3, 1999
CAPN3 protein, human [Supplementary Concept]
RefSeq NM_173090
Date introduced: June 2, 1997
calpain p94 [Supplementary Concept]
amino acid sequence given in first source; a subunit of calpain which is expressed only in skeletal muscle
Date introduced: December 16, 1992
CAPN9 protein, rat [Supplementary Concept]
RefSeq NM_001271140
Date introduced: September 18, 2012
CAPN2 protein, human [Supplementary Concept]
RefSeq NM_001146068
Date introduced: February 9, 2012
GAP-43-3 protein [Supplementary Concept]
GAP-43 fragment lacking about forty N-terminal residues, produced by m-calpain-mediated cleavage of GAP-43 and inhibited m-calpain, but not micro-calpain
Date introduced: August 13, 2007
Capn3 protein, rat [Supplementary Concept]
RefSeq NM_017117
Date introduced: November 2, 2004
Capns1 protein, rat [Supplementary Concept]
RefSeq NM_017118
Date introduced: April 21, 2014
Capn2 protein, mouse [Supplementary Concept]
RefSeq NM_009794
Date introduced: March 26, 2012
CAPN8 protein, Xenopus [Supplementary Concept]
RefSeq NM_001085983
Date introduced: March 31, 2011
Capn5 protein, human [Supplementary Concept]
RefSeq NM_004055
Date introduced: December 26, 2004
calpain 5, rat [Supplementary Concept]
GenBank AF484958
Capn3 protein, mouse [Supplementary Concept]
RefSeq NM_007601
Capn15 protein, mouse [Supplementary Concept]
member of calpain gene family; homologous to small optic lobes protein from Drosophila; RefSeq NM_015830
Date introduced: August 6, 2004
CalpB protein, Drosophila [Supplementary Concept]
GenBank AE003550
Date introduced: May 14, 2004
CAPN1 protein, human [Supplementary Concept]
RefSeq NM_005186
XCL-2 calpain [Supplementary Concept]
encoding an m-type calpain, a calcium-dependent intracellular protease. This protein has all characteristic structures and active sites of canonical calpains; amino acid sequence in first source
Date introduced: February 20, 2002
CAP5.5 protein, Trypanosoma brucei [Supplementary Concept]
a life-cycle-regulated, cytoskeleton-associated protein; member of family of calpain-related proteins in Trypanosoma brucei; GenBank AF321838
Date introduced: September 9, 2001