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Cefotaxime
Semisynthetic broad-spectrum cephalosporin.
Year introduced: 1982
cefotaxime-clavulanic acid drug combination [Supplementary Concept]
Date introduced: June 30, 2023
cefotaxime syn S-oxide [Supplementary Concept]
syn S-oxide derivative of cefotaxime; structure in first source; RN given refers to (5S-(5alpha,6beta,7alpha(Z)))-isomer
Date introduced: July 29, 1980
Ceftriaxone
A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.
Year introduced: 1986
Cefmenoxime
A cephalosporin antibiotic that is administered intravenously or intramuscularly. It is active against most common gram-positive and gram-negative microorganisms, is a potent inhibitor of Enterobacteriaceae, and is highly resistant to hydrolysis by beta-lactamases. The drug has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Year introduced: 1989
CTX-M-27, E coli [Supplementary Concept]
CTX-M-27 showed that residue Gly-240 decreased Km for ceftazidime (205 versus 940 microM), but decreased hydrolytic activity against good substrates, such as cefotaxime (kcat, 113 versus 415 s-1), probably owing to the alteration of beta3 strand positioning during the catalytic process.
Date introduced: September 12, 2003
beta-lactamase SHV-27 [Supplementary Concept]
an extended-spectrum beta-lactamase from Klebsiella pneumoniae; hydrolyzes cefotaxime
Date introduced: July 16, 2001
beta-lactamase CTX-M-10 [Supplementary Concept]
cefotaxime-hydrolyzing beta-lactamase from Escherichia col; GenBank AF255298
Date introduced: May 4, 2001
CTX-M-9 protein, E coli [Supplementary Concept]
cefotaxime-hydrolyzing beta-lactamase; amino acid sequence in first source; GenBank AF252621, AF174129 and AJ416345
Date introduced: August 30, 2000
beta-lactamase SFO-1 [Supplementary Concept]
inducible class A beta-lactamase which hydrolyzes cefotaxime; GenBank AB003148
Date introduced: April 15, 1999
CTX-M-4 protein, Salmonella typhimurium [Supplementary Concept]
a plasmid-mediated cefotaxime-hydrolyzing class A beta-lactamase involved in cephalosporin hydrolysis from Salmonella typhimurium; amino acid sequence in first source; GenBank Y14156
Date introduced: July 1, 1998
DWC 751 [Supplementary Concept]
more potent than ceftazidime & cefotaxime
Date introduced: November 10, 1994
CiaR protein, Streptococcus pneumoniae [Supplementary Concept]
a protein-histidine kinase response regulator associated with the cefotaxime resistance determinant in Streptococcus pneumoniae; amino acid sequence in first source
Date introduced: September 16, 1994
beta-lactamase TEM-10 [Supplementary Concept]
isolated from Klebsiella pneumoniae and Escherichia coli; hydrolyzes ceftazidime faster than aztreonam or cefotaxime
Date introduced: December 15, 1993
beta-lactamase CTX-2 [Supplementary Concept]
from Salmonella mbandaka; pI 5.3; hydrolyzes cefotaxime; inhibited by clavulinic acid
Date introduced: November 1, 1991
benzathine cefotaxime [Supplementary Concept]
structure given in first source; RN given refers to ((R-(6alpha,7beta(Z))))-isomer; RN for compound without isomeric designation not avail 11/90
Date introduced: November 19, 1990
beta-lactamase SHV-3 [Supplementary Concept]
responsible for transferable cefotaxime resistance in clinical isolates of Klebsiella pneumoniae; amino acid sequence given in first source
Date introduced: February 24, 1990
beta-lactamase TEM-4 [Supplementary Concept]
confers high level of resistance to cefotaxime & ceftazidime
Date introduced: October 17, 1989
beta-lactamase CAZ-2 [Supplementary Concept]
from K. pneumoniae; hydrolyzes cefotaxime more easily than ceftazidime
Date introduced: August 8, 1989
beta-lactamase CAZ-1 [Supplementary Concept]
from K. pneumoniae; hydrolyzes ceftazidime more easily than cefotaxime