"Corticosterone" - MeSH

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Select item 680033451.

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

Select item 680194052.

Cytochrome P-450 CYP11B2

A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.

Year introduced: 2015 (1979)

Select item 675378063.

18-Hydroxylase deficiency [Supplementary Concept]

Date introduced: June 25, 2010

Select item 670331124.

corticosterone methyl oxidase I [Supplementary Concept]

converts corticosterone to a labile intermediate 18-hydroxycorticosterone which is then converted to aldosterone by corticosterone methyl oxidase II

Date introduced: January 19, 1982

Select item 670243575.

corticosterone receptor [Supplementary Concept]

Date introduced: June 17, 1980

Select item 674392646.

bovine serum albumin-corticosterone conjugate [Supplementary Concept]

Date introduced: November 16, 2001

Select item 670928407.

18-hydroxytetrahydrocorticosterone [Supplementary Concept]

a major urinary metabolite of 18-hydroxycorticosterone in corticosterone methyl oxidase II deficiency

Date introduced: May 2, 1995

Select item 670503568.

steroid 15-alpha-hydroxylase [Supplementary Concept]

a heme-thiolate enzyme (cytochrome P-450) that catalyzes 15-alpha hydroxylation of testosterone, androstenedione, and progesterone

Date introduced: November 21, 1986

Select item 670242009.

corticosterone sulfate [Supplementary Concept]

Date introduced: May 9, 1980

Select item 6801325510.

Steroid 21-Hydroxylase

An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

Year introduced: 2003 (1978)

Select item 6801325211.

Steroid 11-beta-Hydroxylase

A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

Year introduced: 2003 (1978)

Select item 6800390012.

Desoxycorticosterone

A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE

Select item 6753597813.

Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency [Supplementary Concept]

An autosomal recessive form of congenital adrenal hyperplasia due to defective CORTICOSTEROID biosynthesis, which results in ANDROGEN excess, VIRILIZATION, and HYPERTENSION. The defect causes decreased synthesis of CORTISOL and CORTICOSTERONE in the ZONA FASCICULATA of the ADRENAL GLAND, resulting in accumulation of the precursors CORTODOXONE and 11-deoxycorticosterone, resulting in arterial hypertension. Mutations in the CYP11B1 gene have been identified. OMIM: 202010

Date introduced: August 25, 2010

Select item 6706795714.

corticosterone-21-hemisuccinate [Supplementary Concept]

Date introduced: April 23, 1991

Select item 6706534815.

N(6)-(amido-3-propyl)adenosine [Supplementary Concept]

increases plasma corticosterone in normal rats by acting on adenosine A2 receptors in the pituitary

Date introduced: September 14, 1990

Select item 6706506716.

corticosterone 21-stearate [Supplementary Concept]

Date introduced: August 27, 1990

Select item 6706506617.