Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Deoxyuridine
2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies.
Year introduced: 1966(1964)
Idoxuridine
An analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.
brivudine [Supplementary Concept]
anti-herpes agent
Date introduced: January 1, 1979
Uridine Phosphorylase
An enzyme that catalyzes the transfer of ribose from uridine to orthophosphate, forming uracil and ribose 1-phosphate.
Year introduced: 1991(1975)
5-(N-(2-nitro-5-azidobenzoyl)-3-aminopropen-1-yl)deoxyuridine-5'-triphosphate [Supplementary Concept]
structure in first source
Date introduced: February 25, 1998
5-chloro-5-ethyl-6-methoxy-5,6-dihydro-2'-deoxyuridine [Supplementary Concept]
structure given in first source; RN given refers to (5R,6R)-isomer
Date introduced: June 14, 1994
carbocyclic 5-iodo-2'-deoxyuridine [Supplementary Concept]
RN given refers to (+-)-isomer
Date introduced: April 24, 1990
deoxyuridine 1'-hydroxylase [Supplementary Concept]
forms deoxyribolactone (or ribolactone)+uracil+succinate; requires Fe++, alpha-ketoglutarate & O2
Date introduced: September 24, 1985
5-(2-propenyl)-2'-deoxyuridine [Supplementary Concept]
Date introduced: June 30, 1981
5-propyl-2'-deoxyuridine [Supplementary Concept]
RN given refers to parent cpd
Date introduced: January 1, 1980
Trifluridine
An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557)
Year introduced: 1974(1992)
Fluorodeoxyuridylate
5-Fluoro-2'-deoxyuridylate. An inhibitor of thymidylate synthetase. Formed from 5-fluorouracil or 5-fluorodeoxyuridine.
Deoxyuracil Nucleotides
Uracil nucleotides which contain deoxyribose as the sugar moiety.
Year introduced: 1978
Bromodeoxyuridine
A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.
Year introduced: 1966(1965)
3'-fluoro-5-iodo-2'-deoxyuridine [Supplementary Concept]
Date introduced: July 24, 2007
5-(3-(1-pyrenecarboxamido)propynyl)-2'-deoxyuridine [Supplementary Concept]
Date introduced: June 10, 2007
5-(10-methyl-phenothiazin-3-yl)-2'-deoxyuridine [Supplementary Concept]
Date introduced: July 25, 2006
3'-O-(3-benzenesulfonylfuroxan-4-yl)-5-iodo-2'-deoxyuridine [Supplementary Concept]
a nitric oxide donor that is also an antimetabolite nucleoside for cancer therapy; structure in first source
Date introduced: January 1, 2006
5',6-cyclo-5-hydroxy-5,6-dihydro-2'-deoxyuridine [Supplementary Concept]
Date introduced: March 14, 2003
5-iodo-4'-thio-2'-deoxyuridine [Supplementary Concept]
Date introduced: September 27, 2002