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Fentanyl
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
Year introduced: 1966
fentanyl-BSA conjugate [Supplementary Concept]
commercially available
Date introduced: November 20, 2005
fentanyl isothiocyanate [Supplementary Concept]
specific reagent for irreversible inactivation of delta opiate receptors in rat brain membranes; structure given in first source
Date introduced: February 22, 1983
carfentanil [Supplementary Concept]
Date introduced: January 1, 1978
Innovar [Supplementary Concept]
combination drug containing fentanyl citrate & droperidol
Date introduced: January 1, 1972
butyrfentanyl [Supplementary Concept]
a synthetic opioid; structure in first source
Date introduced: September 22, 2016
Alfentanil
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
Year introduced: 1990
Droperidol
A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Year introduced: 1974(1973)
A3080 [Supplementary Concept]
a synthesized fentanyl derivative with rapid, pronounced opiate agonist activity
Date introduced: February 22, 2002
OHM 3295 [Supplementary Concept]
a fentanyl-related 4-heteroanilido piperidine
Date introduced: March 2, 1995
norfentanyl [Supplementary Concept]
metabolite of fentanyl; RN given refers to parent cpd; structure given in first source
Date introduced: April 7, 1993
despropionylfentanyl [Supplementary Concept]
alpha-methylfentanyl [Supplementary Concept]
combined with 3-methylfentanyl & sold as illicit "China White"
Date introduced: October 1, 1981
3-methylfentanyl [Supplementary Concept]
RN given refers to parent cpd without isomeric designation
Date introduced: July 30, 1981
demethylfentanyl [Supplementary Concept]
main metabolite of fentanyl in horses; RN & N1 from CA Vol 92 Form Index; structure given in first source
Date introduced: March 27, 1981
Hypnorm [Supplementary Concept]
contains fentanyl & fluanisone
beta-hydroxyfentanyl [Supplementary Concept]
fentanyl analog
Date introduced: June 9, 2020
cyclopropylfentanyl [Supplementary Concept]
fentanyl analogue
Date introduced: February 21, 2019
crotonylfentanyl [Supplementary Concept]
Date introduced: February 20, 2019
Remifentanil
A piperidine-propionate derivative and opioid analgesic structurally related to FENTANYL. It functions as a short-acting MU OPIOID RECEPTOR agonist, and is used as an analgesic during induction or maintenance of general anesthesia, following surgery, during childbirth, and in mechanically ventilated patients under intensive care.
Year introduced: 2019 (1991)