MeSH

Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.

A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.

Year introduced: 1986(1975)

Benzopyrroles with the nitrogen at the number two carbon, in contrast to INDOLES which have the nitrogen adjacent to the six-membered ring.

Year introduced: 2008

INDOLES which have two keto groups forming QUINONES like structures of the indole aromatic ring.

Year introduced: 2004

11- to 14-membered macrocyclic lactones with a fused isoindolone. Members with INDOLES attached at the C10 position are called chaetoglobosins. They are produced by various fungi. Some members interact with ACTIN and inhibit CYTOKINESIS.

Year introduced: 1974(1973)

Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.

Year introduced: 1969

Conjugates of betalamic acid with cyclo-dopa, both of which derive from TYROSINE. They appear similar to INDOLES but are biosynthesized by a different path and contain N+. Members are red or violet COLORING AGENTS found in the Caryophyllales order of PLANTS and some BASIDIOMYCETES.

Year introduced: 2006

A plant genus of the family APOCYNACEAE. Members contain voacangine and other INDOLES.

Year introduced: 2003

Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN).

Year introduced: 2002

An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.

Year introduced: 2000

A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.

Year introduced: 1998

A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of MIGRAINE DISORDERS.

Year introduced: 1994

A group of related mycotoxins produced by the pasture fungus Pithomyces chartarum (formerly Sporidesmium bakeri); causes liver damage and facial eczema in cattle and sheep.

Year introduced: 1991(1975)

An organothiophosphorus insecticide that has been used to control pig mange.

Year introduced: 1991(1975)

A laxative that undergoes enterohepatic circulation. It may cause jaundice.

Year introduced: 1991(1983)

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)

Year introduced: 1991(1972)

An antiviral agent effective against pox viruses.

Year introduced: 1991(1975)

Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.

Year introduced: 1991(1975)

Toxins isolated from any species of the genus LYNGBYA or similar chemicals from other sources, including mollusks and micro-organisms. These have been found to be potent tumor promoters. They are biosynthesized from TRYPTOPHAN; VALINE; and METHIONINE nonribosomally (PEPTIDE BIOSYNTHESIS, NUCLEIC ACID-INDEPENDENT).

Year introduced: 1985

A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE, but has only weak antimuscarinic and sedative effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p257)

Year introduced: 1991(1972)