"Mannose" - MeSH

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Select item 680083581.

A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant and Hackh's Chemical Dictionary, 5th ed and Random House Unabridged Dictionary, 2d ed)

Select item 680375822.

Complement Pathway, Mannose-Binding Lectin

Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.

Year introduced: 2003

Select item 680506063.

Mannose-Binding Protein-Associated Serine Proteases

Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.

Year introduced: 2006 (1994)

Select item 680376014.

Mannose-Binding Lectin

A specific mannose-binding member of the collectin family of lectins. It binds to carbohydrate groups on invading pathogens and plays a key role in the MANNOSE-BINDING LECTIN COMPLEMENT PATHWAY.

Year introduced: 2003

Select item 680061555.

Guanosine Diphosphate Mannose

A nucleoside diphosphate sugar which can be converted to the deoxy sugar GDPfucose, which provides fucose for lipopolysaccharides of bacterial cell walls. Also acts as mannose donor for glycolipid synthesis.

Year introduced: 1991(1975)

Select item 680372416.

Mannose-Binding Lectins

A subclass of lectins that are specific for CARBOHYDRATES that contain MANNOSE.

Year introduced: 2003

Select item 680083597.

Mannose-6-Phosphate Isomerase

An enzyme that catalyzes the reversible isomerization of D-mannose-6-phosphate to form D-fructose-6-phosphate, an important step in glycolysis. EC 5.3.1.8.

Year introduced: 1998(1978)

Select item 680042878.

Dolichol Monophosphate Mannose

A lipophilic glycosyl carrier of the monosaccharide mannose in the biosynthesis of oligosaccharide phospholipids and glycoproteins.

Year introduced: 1991(1978)

Select item 21011989.

Mannose Receptor

A member of a family of endocytic receptors. Highly expressed on human macrophages, involved in regulating endocytosis, phagocytosis, and immune responses.

Year introduced: 2022 (1982)

Select item 6801752710.

Receptor, IGF Type 2

A receptor that is specific for IGF-II and mannose-6-phosphate. The receptor is a 250-kDa single chain polypeptide which is unrelated in structure to the type 1 IGF receptor (RECEPTOR, IGF TYPE 1) and does not have a tyrosine kinase domain.

Year introduced: 2000(1993)

Select item 6706985811.

mannose binding protein A [Supplementary Concept]

from rat, MW 31 kDa; predominates in serum & activates complement; acute phase reactant; amino acid sequence given in first source;

Date introduced: August 14, 1991

Select item 6706870212.

mannose(2)-mannosyltransferase-I [Supplementary Concept]

GDP-mannose-dependent alpha 1,2-mannosyltransferase from Saccharomyces cerevisiae; catalyzes the transfer of mannose from GDP-mannose to unsubstituted nonreducing alpha1-6-linked mannose residues in the acceptor molecule

Date introduced: June 3, 1991

Select item 6706696813.

dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase [Supplementary Concept]

catalyzes the transfer of mannose from dolichyl-P-mannose to the Man(5)(GlcNAc)2-PP-dolichol acceptor glycolipid

Date introduced: February 26, 1991

Select item 6702691714.

mannose 1-phosphate guanylyltransferase [Supplementary Concept]

consider also the bifunctional enzyme, phosphomannose isomerase-guanosine diphospho-D-mannose pyrophosphorylase; rfbM has similarity to long-chain, iron-containing alcohol dehydrogenases

Date introduced: November 13, 1980

Select item 201632615.

Perilipin-3

A perilipin that localizes to LIPID DROPLETS; CYTOPLASM; ENDOSOMES; and PLASMA MEMBRANE, especially in MACROPHAGES. It functions as a transporter of free fatty acids to lipid droplets to promote their biogenesis and growth. It is also required for the transport of the MANNOSE-6-PHOSPHATE RECEPTOR from endosomes to the TRANS-GOLGI NETWORK. Its structure consists of four helix bundles that interact with the hydrophobic lipid droplet surface.

Year introduced: 2017 (1983)

Select item 6756360216.

Mannose-Binding Protein Deficiency [Supplementary Concept]

A condition characterized by a mannose-binding lectin (MBL) protein level of less than 100 ng/ml, that occurs in about 5% of people of European descent and in about 10% of sub-Saharan Africans. Most MBL-deficient adults appear healthy, but low levels of MBL are associated with increased risk of infection in toddlers, in cancer patients undergoing chemotherapy, and in organ-transplant patients receiving immunosuppressive drugs, particularly recipients of liver transplants. Polymorphisms in the MBL2 gene have been identified. OMIM: 614372

Date introduced: November 5, 2012

Select item 6742952817.

mannose N-acetylgalactosamine-4-sulfate receptor [Supplementary Concept]

binds oligosaccharides terminating with SO4-4-GalNAcbeta-1-4-GlcNAcbeta or Man

Date introduced: June 26, 2001

Select item 6703531318.

mannose-N-acetylglucosamine receptor [Supplementary Concept]

MW 180,000 high affinity lectin found in rat liver

Date introduced: August 23, 1982

Select item 6703430419.

cation-dependent mannose-6-phosphate receptor [Supplementary Concept]

RefSeq NM_001207024 (M6PR human)