"Midazolam" - MeSH

Select item 680088741.

A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

Year introduced: 1987

Select item 680515442.

Cytochrome P-450 CYP3A

A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

Year introduced: 2006(1980)

Select item 670949703.

6-chloro-2-methyl-4(1H)-quinazolinone [Supplementary Concept]

photodecomposition product of midazolam; structure in first source

Date introduced: September 6, 1995

Select item 670617954.

1-hydroxymethylmidazolam glucuronide [Supplementary Concept]

metabolite of midazolam

Date introduced: December 21, 1989

Select item 670429405.

4-hydroxymidazolam [Supplementary Concept]

metabolite of midazolam; structure given in first source