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Paclitaxel
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Year introduced: 1995
Albumin-Bound Paclitaxel
An injectable formulation of albumin-bound paclitaxel NANOPARTICLES.
Year introduced: 2016 (2002)
paclitaxel poliglumex [Supplementary Concept]
a water-soluble antineoplastic agent; struture in first source
Date introduced: April 2, 2006
cyclotriphosphazene-paclitaxel conjugate [Supplementary Concept]
structure in first source
Date introduced: April 27, 2009
docosahexaenoyl-paclitaxel [Supplementary Concept]
an antineoplastic agent
Date introduced: April 14, 2008
paclitaxel-transferrin [Supplementary Concept]
paclitaxel is a natural product from the bark of the pacific yew it was derivatized on 2' carbon and coupled with transferrin using glutaraldehyde
Date introduced: November 23, 1998
paclitaxel 2'-ethylcarbonate [Supplementary Concept]
Date introduced: November 27, 2008
paclitaxel-Angiopep-2 conjugate [Supplementary Concept]
Antineoplastic Agents, Phytogenic; three paclitaxel molecules linked by a cleavable succinyl ester linkage to a brain peptide vector, Angiopep-2, conjugate named ANG1005; structure in first source
Date introduced: September 25, 2008
130-nm albumin-bound paclitaxel [Supplementary Concept]
enhances tumor radiocurability and therapeutic gain
Date introduced: June 11, 2007
protaxel [Supplementary Concept]
a prodrug of paclitaxel; structure in first source
Date introduced: September 18, 2001
2'-(valyl-leucyl-lysyl-PABC)paclitaxel [Supplementary Concept]
Date introduced: September 6, 2000
poly(ethylene glycol)-conjugated paclitaxel-2'-glycinate [Supplementary Concept]
Date introduced: August 28, 1998
3'-p-hydroxypaclitaxel [Supplementary Concept]
metabolite of paclitaxel; structure in first source
Date introduced: December 6, 1996
6,3'-p-dihydroxypaclitaxel [Supplementary Concept]
3-(2-nitrophenyl)propionic acid-paclitaxel [Supplementary Concept]
a paclitaxel prodrug; structure in first source
Date introduced: January 11, 2018
poly(ethylene oxide)-block-polyphosphoester-graft-paclitaxel [Supplementary Concept]
a pH-senesitive paclitaxel delivery agent; structure in first source
Date introduced: November 1, 2014
Taxoids
A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.
Year introduced: 2004
Epothilones
A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).
Year introduced: 2003
Taxus
Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).
Year introduced: 2000
N-(2-hydroxypropyl)methacrylamide copolymer-paclitaxel conjugate [Supplementary Concept]
Date introduced: July 27, 2013