"Podophyllin" - MeSH

Select item 680110331.

Caustic extract from the roots of Podophyllum peltatum and P. emodi. It contains PODOPHYLLOTOXIN and its congeners and is very irritating to mucous membranes and skin. Podophyllin is a violent purgative that may cause CNS damage and teratogenesis. It is used as a paint for warts, skin neoplasms, and senile keratoses.

Year introduced: 1972(1964)

Select item 680281442.

Podophyllum peltatum

A plant of the genus PODOPHYLLUM, family BERBERIDACEAE (sometimes classified as Podophyllaceae) which is the source of PODOPHYLLIN and of PODOPHYLLOTOXIN that inhibits DNA TOPOISOMERASES, TYPE II. It is different from the European mandrake, MANDRAGORA.

Year introduced: 2002

Select item 680110343.

Podophyllotoxin

A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.

Year introduced: 1973

Select item 674150324.

picropodophyllin [Supplementary Concept]

isolated from American May apple (Podophyllum); inhibits IGF-I autophosphorylation without interfering with tyrosine kinase activity

Date introduced: November 2, 2000

Select item 670238165.

bursehernin [Supplementary Concept]

a dibenzylbutyrolactone found in PODOPHYLLIN; analog of podorhizol; RN & N1 from CA Vol 90 Form Index; structure in first source

Date introduced: May 1, 1980

Select item 670031706.

mitopodozide [Supplementary Concept]

an ethylhydrazide derivative of podophyllic acid; RN given refers to cpd without isomeric designation;