"Sincalide" - MeSH

Select item 680128441.

An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.

Year introduced: 1984

Select item 670707562.

sincalide, Phe(CH2SO3Na)(2)- [Supplementary Concept]

Date introduced: October 4, 1991

Select item 670654923.

sincalide, pGlu- [Supplementary Concept]

Date introduced: September 26, 1990

Select item 680119494.

Receptors, Cholecystokinin

Cell surface proteins that bind cholecystokinin (CCK) with high affinity and trigger intracellular changes influencing the behavior of cells. Cholecystokinin receptors are activated by GASTRIN as well as by CCK-4; CCK-8; and CCK-33. Activation of these receptors evokes secretion of AMYLASE by pancreatic acinar cells, acid and PEPSIN by stomach mucosal cells, and contraction of the PYLORUS and GALLBLADDER. The role of the widespread CCK receptors in the central nervous system is not well understood.

Year introduced: 1987

Select item 680201095.

Devazepide

A derivative of benzodiazepine that acts on the cholecystokinin A (CCKA) receptor to antagonize CCK-8's (SINCALIDE) physiological and behavioral effects, such as pancreatic stimulation and inhibition of feeding.

Year introduced: 1999

Select item 670812706.

N-(3,4-phenoxyacetyl)-glutamic acid-1-di-n-propylamide [Supplementary Concept]

sincalide antagonist

Date introduced: June 17, 1993

Select item 670795307.

desulfated sincalide [Supplementary Concept]

cholecystokinin receptor antagonist

Date introduced: March 4, 1993

Select item 670691918.

propionyl CCK octapeptide sulfate [Supplementary Concept]

metabolite of sincalide