MeSH

Heterocyclic compounds where the ring system is composed of three CARBON atoms, a SULFUR and NITROGEN atoms.

Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.

Year introduced: 2007

THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).

Year introduced: 2004

Compounds with a benzene ring fused to a thiazole ring.

Year introduced: 2006

A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.

Year introduced: 1998

An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A.

Year introduced: 1997

A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.

Year introduced: 1992

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

Year introduced: 1990

A dopamine-beta-hydroxylase inhibitor.

Year introduced: 1991(1975)

A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)

Year introduced: 1994,1973-1974(1971-1972)

Thiamine antagonist, antimetabolite.

Year introduced: 1991(1975)

An antischistosomal agent that has become obsolete.

Year introduced: 1973(1972)

A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.

Year introduced: 1991(1975)

A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.

Year introduced: 1991(1975)

A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors.

Year introduced: 1968

A nematocide effective against a variety of gastrointestinal parasites in cattle, sheep, and horses.

Year introduced: 1991(1975)

Pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.

Year introduced: 1991(1985)

An amidinopenicillanic acid derivative with broad spectrum antibacterial action.

Year introduced: 1985

an analgesic & antipyretic with anti-inflammatory properties; minor descriptor (75-86); on-line & INDEX MEDICUS search THIAZOLES (75-86); RN given refers to parent cpd

Date introduced: August 1, 1986