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Verapamil
A calcium channel blocker that is a class IV anti-arrhythmia agent.
Year introduced: 1984
quinidine, verapamil drug combination [Supplementary Concept]
combination of verapamil & quinidine
Date introduced: May 27, 1982
Cytochrome P-450 CYP3A
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Year introduced: 2006(1980)
Nimustine
Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
Year introduced: 1989
Gallopamil
Coronary vasodilator that is an analog of iproveratril (VERAPAMIL) with one more methoxy group on the benzene ring.
Year introduced: 1987(1984)
ADAAV solution [Supplementary Concept]
contains adenine, dextran, albumin, allopurinol & verapamil
Date introduced: January 26, 1994
Osaka University cocktail [Supplementary Concept]
contains prostacyclin analog (30 ug/kg), verapamil (0.5 mg/kg), propranolol (0.5 mg/kg), allopurinol (5 mg/kg) & nafamostat mesilate (2 mg/kg) in an electrolite solution
alpha-(1-(3-(N-(1-(2-(3,4-dimethoxyphenyl)ethyl))-N-methylamino)cyclohexyl))-alpha-isopropyl-3,4-dimethoxybenzeneacetonitrile [Supplementary Concept]
structure given in first source; used to study effect of molecular flexibility on verapamil
Date introduced: May 17, 1993
Bodipy-verapamil [Supplementary Concept]
structure given in first source; substrate for P glycoprotein in MDR cells
Date introduced: November 20, 1991
UCLA-formula organ preservation solution [Supplementary Concept]
contains KCl, NAH2PO4, NA2HPO4, glucose, mannitol, insulin, verapamil & serum
Date introduced: October 16, 1991
(N-benzoyl)-5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropyl-N-4-azidobenzoylpentylamine [Supplementary Concept]
Date introduced: October 2, 1989
phenoptin [Supplementary Concept]
a calcium channel blocker reported in 2 Russian articles; no other info available 12/85; see Verapamil, Finoptin is a TRD which could be a translation variant of fenoptin
Date introduced: December 6, 1985
alpha-(3-aminopropyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile [Supplementary Concept]
N-demethylated analog of verapamil
Date introduced: January 1, 1978
norverapamil [Supplementary Concept]
N-demethylated active metabolite of verapamil; RN given refers to parent cpd without isomeric designation; structure in second source