MeSH

The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research into the nature of the aging process and diseases associated with the later stages of life. The Institute was established in 1974.

Year introduced: 2008

Changes in the organism associated with senescence, occurring at an accelerated rate.

Year introduced: 1998

The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.

Year introduced: 1990

The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.

Year introduced: 1967(1965)

The development and maintenance of optimal physical, mental, spiritual, and social well-being and function with advancing age.

Year introduced: 2018

Phenomenon that occurs when learning and memory abilities decrease naturally due to age.

Year introduced: 2016

Permanent G1 CELL CYCLE ARREST of the T-cell, resulting from ageing, oncogene activation, telomere degradation, epigenomic changes, or exposure to stressful stimuli including reactive-oxygen species, ionizing radiation, or certain chemicals.

Year introduced: 2024

The study of the BIOLOGY; BIOCHEMISTRY; and PHYSIOLOGY of AGING and the AGED and age-related diseases such as CARDIOVASCULAR DISEASES; DIABETES MELLITUS; and CANCER, as well as debilitating conditions like ARTHRITIS; FATIGUE; and FRAILTY.

Year introduced: 2022

Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.

Year introduced: 2018 (1992)

Neuronal loss in the hippocampal regions of CA1 and CA4 and less severely CA2 and CA3. Additional loss of hippocampal stratum radiatum, hippocampal atrophy and ASTROGLIOSIS are common. Hippocampal sclerosis is associated with intractable TEMPORAL LOBE EPILEPSY.

Year introduced: 2023

The pattern of any process, or the interrelationship of phenomena, which affects growth or change within a population.

Year introduced: 1976

Prematurely aged appearance, delayed bone maturation, acro-osteolysis, and brachydactyly

Date introduced: August 25, 2010

In plants, similarly as in animals, an age-dependent irreversible process of changes leading to the arrest of CELL DIVISION and/or PROGRAMMED CELL DEATH.

Year introduced: 2022

A housing and community arrangement that maximizes independence and self-determination.

Year introduced: 2010

An autosomal dominant disorder manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to Mondini type cochlear defect and stapes fixation. (Jablonski's Dictionary of Syndromes and Eponymic Diseases, 2d ed)

Year introduced: 1997

An autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin changes, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, baldness, and a high incidence of neoplastic disease.

Year introduced: 1998

Date introduced: November 5, 2012

Premature aging syndrome with osteosarcoma, cataracts, diabetes mellitus, osteoporosis, erythroid macrocytosis, severe growth and developmental deficiency

Date introduced: August 25, 2010

Date introduced: November 29, 2022