MeSH

The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.

Year introduced: 1966

RefSeq NM_172943

Date introduced: March 21, 2014

RefSeq NM_006020

Date introduced: July 29, 2005

A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).

Year introduced: 2017

RefSeq NM_028070

Date introduced: December 26, 2013

RefSeq NM_032306

Date introduced: July 19, 2013

RefSeq NM_017758

Date introduced: July 31, 2011

RefSeq NM_017621

Date introduced: April 24, 2011

RefSeq NM_138775

Date introduced: May 31, 2010

RefSeq NM_026303

Date introduced: April 7, 2010

RefSeq NM_001102565

Date introduced: June 14, 2008

RefSeq NM_026944

Date introduced: July 20, 2006

RefSeq NM_175016

Date introduced: July 20, 2006

RefSeq NM_001001655

Date introduced: June 4, 2004

RefSeq NM_139178

Date introduced: June 4, 2004

plays a major role in DNA repair of alkylation damage; removes methyl groups from damaged DNA and transfers them to its own cysteine residue; can then serve as a transcription factor for a variety of genes including alkA

Date introduced: July 23, 1985