Calcitriol - MeSH

Select item 680021171.

The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.

Year introduced: 1982

Select item 680181672.

Receptors, Calcitriol

Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.

Year introduced: 1994

Select item 680656683.

Vitamin D3 24-Hydroxylase

A cytochrome P-450 enzyme that has specificity for CHOLECALCIFEROL (Vitamin D3). It hydroxylates the molecule at carbon position 24.

Year introduced: 2015 (1978)

Select item 675475124.

eldecalcitol [Supplementary Concept]

structure in first source

Date introduced: March 5, 2010

Select item 670968195.

25-O-ethyl-calcitriol [Supplementary Concept]

structure given in first source

Date introduced: December 21, 1995

Select item 670875916.

22-dehydro-1,25-dihydroxy-24-dihomovitamin D3 [Supplementary Concept]

an interleukin-6 and 8 antagonist

Date introduced: July 5, 1994

Select item 670875907.

22-dehydro-1,25-dihydroxy-24-homovitamin D3 [Supplementary Concept]

an interleukin-6 and 8 antagonist

Date introduced: July 5, 1994

Select item 670628088.

24,24-difluoro-1,25-dihydroxy-26,27-dimethylvitamin D3 [Supplementary Concept]

RN & structure given in first source

Date introduced: March 8, 1990

Select item 670526069.

1,25-dihydroxyvitamin D3-23,26-lactol [Supplementary Concept]

in calcitriol proposed metabolic pathway; structure given in first source; RN given refers to ((23R,25S)-isomer); RN for cpd without isomeric designation not available 1/89

Date introduced: June 23, 1987

Select item 6705240410.

26-homo-1,25-dihydroxyvitamin D3 [Supplementary Concept]

structure given in first source

Date introduced: June 5, 1987

Select item 6705240311.

24-homo-1,25-dihydroxyvitamin D3 [Supplementary Concept]

structure given in first source

Date introduced: June 5, 1987

Select item 6705188312.

maxacalcitol [Supplementary Concept]

structure given in first source