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Items: 20

1.

Corticosterone

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

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Cytochrome P-450 CYP11B2

A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.

Year introduced: 2015 (1979)

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steroid 15-alpha-hydroxylase [Supplementary Concept]

a heme-thiolate enzyme (cytochrome P-450) that catalyzes 15-alpha hydroxylation of testosterone, androstenedione, and progesterone

Date introduced: November 21, 1986

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18-hydroxytetrahydrocorticosterone [Supplementary Concept]

a major urinary metabolite of 18-hydroxycorticosterone in corticosterone methyl oxidase II deficiency

Date introduced: May 2, 1995

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corticosterone 21-oleate [Supplementary Concept]

Rn given refers to (11beta,21(Z)-isomer

Date introduced: August 27, 1990

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cortifen [Supplementary Concept]

Russian drug; complex ester of 11-deoxy-17-hydroxycorticosterone & chlorphenacyl

Date introduced: February 7, 1989

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corticosterone methyl oxidase I [Supplementary Concept]

converts corticosterone to a labile intermediate 18-hydroxycorticosterone which is then converted to aldosterone by corticosterone methyl oxidase II

Date introduced: January 19, 1982

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corticosterone nitroxide [Supplementary Concept]

Date introduced: September 26, 1980

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corticosterone methyl oxidase II [Supplementary Concept]

catalyzes the ultimate step on aldosterone biosynthesis: from 18-hydroxycorticosterone to aldosterone

Date introduced: July 29, 1980

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