Dactinomycin
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Year introduced: 1966
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Subheadings:
Tree Number(s): D03.633.300.200, D04.345.566.252, D12.644.641.252
MeSH Unique ID: D003609
Registry Number: 1CC1JFE158
Entry Terms:
- Actinomycin D
- Meractinomycin
- Actinomycin
- Cosmegen
- Lyovac-Cosmegen
- LyovacCosmegen
- Lyovac Cosmegen
- Cosmegen Lyovac
- Lyovac, Cosmegen
Pharmacologic Action: